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FLASH GENE

Symbol

AP2A1

contributors: - updated : 01-06-2006

HGNC name	adaptor-related protein complex 2, alpha 1 subunit
HGNC id	561

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 3499 107.6 977 forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon Scorilas variant 2 - splicing 3433 105.1 955 widely expressed in tissues and also in breast cancer and in prostate carcinoma cells Scorilas lacking an internal exon

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive salivary gland         Nervous brain           brain hindbrain cerebellum       spinal cord

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular     Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text

forebrain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Ap2a1 (98.5pc)

Homologene

FAMILY

adaptor complexes large subunits family

CATEGORY

adaptor , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	endocytic coated vesicles

basic FUNCTION

AP2 adaptor complex linking clathrin to receptors in coated vesicles, clathrin-associated protein complexes are believed to interact with cytoplasmic domains of transmembrane proteins leading to their selection and concentration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

endocytosis transport , cellular trafficking transport

PATHWAY

metabolism

signaling

a component

subunit of AP-2 adaptor complex, clathrin coat assembly complex

INTERACTION

DNA

RNA

small molecule

protein

HIP1

cell & other

REGULATION

activated by

the autonomous E1A,requiring derepression of AP2A promoter by interaction of E1A with KLF12 corepressor CTBP1

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS