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FLASH GENE
Symbol COQ7 contributors: mct/npt - updated : 07/11/2008
HGNC name coenzyme Q7 homolog, ubiquinone (yeast)
HGNC id 2244
Location 16p12.3      Physical location : 19.078.916 - 19.091.415
Synonym name
  • placental protein KG-20
  • ubiquinone biosynthesis protein
  • coenzyme Q, 7 (rat, yeast) homolog
  • timing protein
    • Synonym symbol(s) CAT5, CLK-1, CLK1
    DNA
    TYPE functioning gene
    STRUCTURE 12.43 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D16S499 - COQ7 - D16S2974 - D16S403 - D16S401 - qter
    Authors Asaumi (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2591 24 217 - Stenmark (2001)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three hydrophobic regions N terminal, central and C terminal
  • a putative discrimination of mitochondrial targeting sequence (hTTDISC)
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae cat5p
    homolog to C.elegans longevity gene clk1
    Homologene
    FAMILY
  • di-iron containing oxidases/hydroxylases family
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • catalyzes the production of coenzyme Q (CoQ) in mitochondria
  • involved in ubiquinone biosynthesis and hence, is required for respiration and gluconeogenesis
  • functioning as a hydroxylase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism carbohydrate
    signaling
    gluconeogenesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS