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FLASH GENE
Symbol COQ7 contributors: mct/npt - updated : 07/11/2008
HGNC name coenzyme Q7 homolog, ubiquinone (yeast)
HGNC id 2244
Location 16p12.3      Physical location : 19.078.916 - 19.091.415
Synonym name
  • placental protein KG-20
  • ubiquinone biosynthesis protein
  • coenzyme Q, 7 (rat, yeast) homolog
  • timing protein
  • Synonym symbol(s) CAT5, CLK-1, CLK1
    DNA
    TYPE functioning gene
    STRUCTURE 12.43 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D16S499 - COQ7 - D16S2974 - D16S403 - D16S401 - qter
    Authors Asaumi (99)
    Physical map
    XYLT1 16p13.1-p12 xylosyltransferase I LOC146110 16p13.12 similar to 60S ribosomal protein L7 LOC390678 16 similar to Group X secretory phospholipase A2 precursor (Phosphatidylcholine 2-acylhydrolase GX) (GX sPLA2) (sPLA2-X) LOC339047 16p13.12 hypothetical protein LOC339047 PKD1P4 16p13.3 hypothetical protein LOC339047 PKD1P5 16p13.3 hypothetical protein LOC339047 LOC283820 16p13.12 hypothetical protein LOC283820 PM5 16p13.12 hypothetical protein LOC283820 LOC388217 16 hypothetical gene supported by AF168791; NM_001171 RPS15A 16p ribosomal protein S15a ARL6IP 16p12-p11.2 ADP-ribosylation factor-like 6 interacting protein SMG1 16p13.11 PI-3-kinase-related kinase SMG-1 TMC7 16p13.11 transmembrane channel-like 7 COQ7 16p13.11-p12.3 coenzyme Q7 homolog, ubiquinone (yeast) LOC162073 16p13.11 hypothetical protein LOC162073 LOC51760 16p13.11 B/K protein LOC388218 16 similar to QRWT5810 LOC388219 16 LOC388219 TMC5 16p13.11 transmembrane channel-like 5 MIR16 16p12-p11.2 membrane interacting protein of RGS16 CP110 16p13.11 CP110 protein MGC16824 16p13.11 esophageal cancer associated protein MGC35048 16p13.11 hypothetical protein MGC35048 GPRC5B 16p12 G protein-coupled receptor, family C, group 5, member B LOC124274 16p13.11 similar to putative G-protein coupled receptor LOC390679 16 similar to sal-like 4 GP2 9q21.11-q21.2 glycoprotein 2 (zymogen granule membrane) UMOD 16p13.11 uromodulin (uromucoid, Tamm-Horsfall glycoprotein) LOC204474 16p13.11 hypothetical protein LOC204474 FLJ20581 16p13.11 hypothetical protein FLJ20581 LOC123876 16p13.11 hypothetical protein LOC123876 LOC348158 16p13.11 xenobiotic/medium-chain fatty acid:CoA ligase BUCS1 16p13;.1 butyryl Coenzyme A synthetase 1 LOC390680 16 similar to Hypothetical protein MGC56918 FLJ20274 16p13.11 hypothetical protein FLJ20274 SAH 16p13.11 SA hypertension-associated homolog (rat) MGC16943 16p13.11 similar to RIKEN cDNA 4933424N09 gene LOC81691 16p13.11 exonuclease NEF-sp MGC48972 16p13.11 hypothetical protein MGC48972 LOC57149 16p11.2 hypothetical protein A-211C6.1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2591 24 217 - Stenmark (2001)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three hydrophobic regions N terminal, central and C terminal
  • a putative discrimination of mitochondrial targeting sequence (hTTDISC)
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae cat5p
    homolog to C.elegans longevity gene clk1
    Homologene
    FAMILY
  • di-iron containing oxidases/hydroxylases family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • catalyzes the production of coenzyme Q (CoQ) in mitochondria
  • involved in ubiquinone biosynthesis and hence, is required for respiration and gluconeogenesis
  • functioning as a hydroxylase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism carbohydrate
    signaling
    gluconeogenesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS