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FLASH GENE

Symbol

CNTN2

contributors: mct/npt - updated : 13-03-2015

HGNC name	contactin 2 (axonal)
HGNC id	2172

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005076 23 - 7650 NP_005067 - 1040 - Tsiotra (1993)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart conducting system       Endocrine neuroendocrine pituitary       Nervous brain basal nuclei corpus callosum       brain hindbrain medulla oblongata       ganglia sensory ganglia dorsal root   highly   nerve cranial nerve

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Nervous Schawnn cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	cerebellar developing neurons

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six Ig-like and four FNIII-like extracellular domains
	a single transmembrane segment (TM)
	a short cytoplasmic tail

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to rattus transient axonal glycoprotein (Tag-1)

Homologene

FAMILY	immunoglobulin superfamily
	contactin family

CATEGORY

adhesion , regulatory , protooncogene

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	TAX1BP1 and CNTN2 colocalize into intranuclear speckles that partially overlap with but are not identical to the PML oncogenic domains

basic FUNCTION	playing a role in the initial growth and guidance of axons, and in glial tumorigenesis
	transcriptional regulator that interacts with a large number of host cell factors
	involved in axonal re-modelling, neuron-glia interactions, and glial cell migration
	modulating negatively neurogenesis through APBB1 in the CNTN2-APP signalling pathway
	cell adhesion molecule critical for neuronal patterning and ion channel clustering (Pallante 2010)
	increasing APP intracellular domain release and triggers FE65-dependent transcriptional activity in a gamma-secretase-dependent manner by binding to APP (Tachi 2010)
	inhibits TGFB2-mediated neuronal cell death via APP by attenuating the binding of TGFB2 to APP (Tachi 2010)
	CNTN1, CNTN2 and L1-like proteins (NRCAM) play a significant role in modulating SHH-induced neuronal precursor proliferation
	juxtaparanodal proteins CNTNAP2 and CNTN2 regulate diet-induced obesity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	neurogenesis

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with NRCAM for the development of the cerebellar system
	binds TAX1BP1 directly, induces the dissociation of TAX1BP1 from the glucocorticoid receptor-containing protein complex, and represses the coactivator function of TAX1BP1
	interaction with SEMA3D (SEMA3D and CNTN2 regulate the motility and behavior of growth cones extending in their natural environment and demonstrate that two different axon branches from one neuron respond differently to guidance cues) (Liu 2005)
	link between CNTN2-induced IKK activation and the centrosome (Kfoury 2008)
	myelin regulates both trafficking and activity of KCNA1, KCNA2 channels along hippocampal axons through CNTN2
	BACE1-mediated CNTN2 cleavage tightly regulates the surface expression of CNTN2 in neuronal cells
	SEMA5B inhibits the growth of NGF-dependent sensory axons and this effect is mediated in part through the cell adhesion molecule CNTN2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

BAFME5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in gliomas (high-grade) constitutional     --over   in the brain after injury

Susceptibility

Variant & Polymorphism

Candidate gene	novel marker of the specialized cardiac conduction system (Pallante 2010)
	may be an age-related reduction of expression that may predispose neuros to death, mechanism that may contribute to the onset and the progression of Alzeihmer's disease-relevant neuronal cell death (Tachi 2010)
Marker
Therapy target

ANIMAL & CELL MODELS