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FLASH GENE
Symbol CNTN2 contributors: mct/npt - updated : 13-03-2015
HGNC name contactin 2 (axonal)
HGNC id 2172
DNA
TYPE functioning gene
STRUCTURE 34.80 kb     23 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 7650 - 1040 - Tsiotra (1993)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheartconducting system   
Endocrineneuroendocrinepituitary   
Nervousbrainbasal nucleicorpus callosum  
 brainhindbrainmedulla oblongata  
 gangliasensory gangliadorsal root highly
 nervecranial nerve   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
NervousSchawnn cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text cerebellar developing neurons
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six Ig-like and four FNIII-like extracellular domains
  • a single transmembrane segment (TM)
  • a short cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus transient axonal glycoprotein (Tag-1)
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • contactin family
  • CATEGORY adhesion , regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text TAX1BP1 and CNTN2 colocalize into intranuclear speckles that partially overlap with but are not identical to the PML oncogenic domains
    basic FUNCTION
  • playing a role in the initial growth and guidance of axons, and in glial tumorigenesis
  • transcriptional regulator that interacts with a large number of host cell factors
  • involved in axonal re-modelling, neuron-glia interactions, and glial cell migration
  • modulating negatively neurogenesis through APBB1 in the CNTN2-APP signalling pathway
  • cell adhesion molecule critical for neuronal patterning and ion channel clustering (Pallante 2010)
  • increasing APP intracellular domain release and triggers FE65-dependent transcriptional activity in a gamma-secretase-dependent manner by binding to APP (Tachi 2010)
  • inhibits TGFB2-mediated neuronal cell death via APP by attenuating the binding of TGFB2 to APP (Tachi 2010)
  • CNTN1, CNTN2 and L1-like proteins (NRCAM) play a significant role in modulating SHH-induced neuronal precursor proliferation
  • juxtaparanodal proteins CNTNAP2 and CNTN2 regulate diet-induced obesity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NRCAM for the development of the cerebellar system
  • binds TAX1BP1 directly, induces the dissociation of TAX1BP1 from the glucocorticoid receptor-containing protein complex, and represses the coactivator function of TAX1BP1
  • interaction with SEMA3D (SEMA3D and CNTN2 regulate the motility and behavior of growth cones extending in their natural environment and demonstrate that two different axon branches from one neuron respond differently to guidance cues) (Liu 2005)
  • link between CNTN2-induced IKK activation and the centrosome (Kfoury 2008)
  • myelin regulates both trafficking and activity of KCNA1, KCNA2 channels along hippocampal axons through CNTN2
  • BACE1-mediated CNTN2 cleavage tightly regulates the surface expression of CNTN2 in neuronal cells
  • SEMA5B inhibits the growth of NGF-dependent sensory axons and this effect is mediated in part through the cell adhesion molecule CNTN2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BAFME5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in gliomas (high-grade)
    constitutional     --over  
    in the brain after injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • novel marker of the specialized cardiac conduction system (Pallante 2010)
  • may be an age-related reduction of expression that may predispose neuros to death, mechanism that may contribute to the onset and the progression of Alzeihmer's disease-relevant neuronal cell death (Tachi 2010)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS