Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

TNFAIP1

contributors: mct/npt/pgu - updated : 15-03-2016

HGNC name	tumor necrosis factor, alpha-induced protein 1 (endothelial)
HGNC id	11894

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a BTB(POZ) domain

HOMOLOGY

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endosome
	intracellular,nucleus,nucleolus

basic FUNCTION	may play roles in the DNA repair, DNA synthesis, cell apoptosis
	may be involved in the process of cancer
	may function in DNA replication, apoptosis and human diseases
	KCTD13 and TNFAIP1 are interacting partners to RND proteins which influence the development of cortical neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CSNK2B could phosphorylate TNFAIP1, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA)
	TNFAIP1 overexpression resulted in ubiquitin-mediated degradation of KCTD10 proteins
	CREB1 is a negative regulator of the TNFAIP1 gene
	KCTD13 and TNFAIP1 are interacting partners to RND proteins which influence the development of cortical neurons

cell & other

REGULATION

induced by	TNF in umbilical vein endothelial cells
		TNF-alpha, interleukin-1 beta and lipopolysaccharide (LPS)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   can accelerate the apoptosis of HeLa cell tumoral     --over   significantly increased in osteosarcoma tissues compared with that in adjacent non-cancerous tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     TNFAIP1 may act as a potential therapeutic target for the treatment of cancer

ANIMAL & CELL MODELS