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FLASH GENE

Symbol

TNFAIP1

contributors: mct/npt/pgu - updated : 15-03-2016

HGNC name	tumor necrosis factor, alpha-induced protein 1 (endothelial)
HGNC id	11894

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q11.2      Physical location : 26.662.547 - 26.674.033
Synonym name	protein B12
	BTB/POZ domain-containing Adaptor for CUL3-mediated RHOA Degradation family member 2
Synonym symbol(s)	B12, B61, EDP1, MGC2317, Bacurd2, BTBD34

DNA

TYPE	functioning gene
STRUCTURE	11.49 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	one functional Sp1-binding site within the human TNFAIP1 core promoter region, and Sp1 is supposed to be involved in the elevation of TNFAIP1 in response to TNF induction, and thus participate in inflammation-associated angiogenesis

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021137 7 - 3822 NP_066960 - 316 - 1992 1370465

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessels capillary       Digestive liver       highly Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining endothelium     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a BTB(POZ) domain

HOMOLOGY

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endosome
	intracellular,nucleus,nucleolus

basic FUNCTION	may play roles in the DNA repair, DNA synthesis, cell apoptosis
	may be involved in the process of cancer
	may function in DNA replication, apoptosis and human diseases
	KCTD13 and TNFAIP1 are interacting partners to RND proteins which influence the development of cortical neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CSNK2B could phosphorylate TNFAIP1, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA)
	TNFAIP1 overexpression resulted in ubiquitin-mediated degradation of KCTD10 proteins
	CREB1 is a negative regulator of the TNFAIP1 gene
	KCTD13 and TNFAIP1 are interacting partners to RND proteins which influence the development of cortical neurons

cell & other

REGULATION

induced by	TNF in umbilical vein endothelial cells
		TNF-alpha, interleukin-1 beta and lipopolysaccharide (LPS)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   can accelerate the apoptosis of HeLa cell tumoral     --over   significantly increased in osteosarcoma tissues compared with that in adjacent non-cancerous tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     TNFAIP1 may act as a potential therapeutic target for the treatment of cancer

ANIMAL & CELL MODELS