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FLASH GENE
Symbol OPLAH contributors: mlc/np - updated : 09-11-2007
HGNC name 5-oxoprolinase (ATP-hydrolysing)
HGNC id 8149
Location 8q24      Physical location : 145.106.166 - 145.115.584
Synonym name
  • pyroglutamase
  • 5-oxo-L-prolinase
    • Synonym symbol(s) OPLA, 5-Opase, DKFZP434H244
    EC.number 3.5.2.9
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 8.00 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 3985 137.4 1288 - Watanabe (2004)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
     salivary gland   highly
    Reproductivemale systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • oxoprolinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP
    • and inorganic phosphate
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS