basic FUNCTION
| 5'-DNA kinase and 3'phosphatase facilitating DNA repair of DNA single strand breaks caused by ionizing radiation or oxidative damage |
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direct, specific role in double-strand break repair  |
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bifunctional enzyme possessing a 5'-DNA kinase activity and a 3'-phosphatase activity |
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required to process unligatable strand break termini generated directly by many genotoxic agents |
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participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination |
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involved in multiple repair pathways (BER, SSBR, and double strand break repair), so its abundance may be a requirement for the cells |
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involved in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway |
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may have a role in several DNA repair pathways  |
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implicated in repair of both double-strand breaks (DSBs) and single-strand breaks  |
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critical role of NEIL2 and PNKP in maintenance of the mammalian mitochondrial genome  |
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is a relatively abundant DNA repair protein in mitochondria |
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plays a major role in repair of oxidized bases in the mitochondrial genome  |
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is a dual-function enzyme with a key role in different pathways of DNA damage repair. DNA repair disorders can result in accelerated cell death, leading to underdevelopment and neurodegeneration |
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dual-function enzyme with a key role in different pathways of DNA-damage repair  |