| 1 | CSNK2A2, PNKP, XRCC1
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| XRCC1-mediated repair of strand breaks independent of PNKP binding.
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| Horton JK, Stefanick DF, Zhao ML, Janoshazi AK, Gassman NR, Seddon HJ, Wilson SH.
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| DNA Repair (Amst) 60:52-63. doi: 10.1016/j.dnarep.2017.10.007. Epub 2017 Oct 19.
2017
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| 2 | PNKP, XRCC1
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| XRCC1-mediated repair of strand breaks independent of PNKP binding.
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| Horton JK, Stefanick DF, Zhao ML, Janoshazi AK, Gassman NR, Seddon HJ, Wilson SH.
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| DNA Repair (Amst) 60:52-63. doi: 10.1016/j.dnarep.2017.10.007. Epub 2017 Oct 19.
2017
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| 3 | PARP1, PARP2, PNKP, XRCC1
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| Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin.
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| Hanzlikova H, Gittens W, Krejcikova K, Zeng Z, Caldecott KW.
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| Nucleic Acids Res 45(5):2546-2557. doi: 10.1093/nar/gkw1246.
2017
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| 4 | AOA4, PNKP
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| Mutations in PNKP Cause Recessive Ataxia with Oculomotor Apraxia Type 4.
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| Bras J, Alonso I, Barbot C, Costa MM, Darwent L, Orme T, Sequeiros J, Hardy J, Coutinho P, Guerreiro R.
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| Am J Hum Genet 96(3):474-9. doi: 10.1016/j.ajhg.2015.01.005. Epub 2015 Feb 26.
2015
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| 5 | PNKP
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| Progressive cerebellar atrophy and polyneuropathy: expanding the spectrum of PNKP mutations.
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| Poulton C, Oegema R, Heijsman D, Hoogeboom J, Schot R, Stroink H, Willemsen MA, Verheijen FW, van de Spek P, Kremer A, Mancini GM.
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| Neurogenetics 14(1):43-51. doi: 10.1007/s10048-012-0351-8. Epub 2012 Dec 9.
2013
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| 6 | MCSZ, PNKP
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| Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair.
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| Reynolds JJ, Walker AK, Gilmore EC, Walsh CA, Caldecott KW.
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| Nucleic Acids Res 40(14):6608-19. doi: 10.1093/nar/gks318. Epub 2012 Apr 15.
2012
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| 7 | ATM, PNKP
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| ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.
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| Segal-Raz H, Mass G, Baranes-Bachar K, Lerenthal Y, Wang SY, Chung YM, Ziv-Lehrman S, Ström CE, Helleday T, Hu MC, Chen DJ, Shiloh Y.
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| EMBO Rep 12(7):713-9. doi: 10.1038/embor.2011.96.
2011
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| 8 | MCSZ, PNKP
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| Mutations in PNKP cause microcephaly, seizures and defects in DNA repair.
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| Shen J, Gilmore EC, Marshall CA, Haddadin M, Reynolds JJ, Eyaid W, Bodell A, Barry B, Gleason D, Allen K, Ganesh VS, Chang BS, Grix A, Hill RS, Topcu M, Caldecott KW, Barkovich AJ, Walsh CA.
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| Nat Genet 42(3):245-9. Epub 2010 Jan 31. 2010
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| 9 | PNKP, XRCC1
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| Independent mechanisms of stimulation of polynucleotide kinase/phosphatase by phosphorylated and non-phosphorylated XRCC1.
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| Lu M, Mani RS, Karimi-Busheri F, Fanta M, Wang H, Litchfeld DW, Weinfeld M.
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| Nucleic Acids Res 38(2):510-21. Epub 2009 Nov 12.PMID: 19910369 2010
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| 10 | PNKP, XRCC4
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| Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.
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| Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M.
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| J Biol Chem 285(48):37619-29. Epub 2010 Sep 17.
2010
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| 11 | APLF, PNKP, XRCC1
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| Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK.
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| Ali AA, Jukes RM, Pearl LH, Oliver AW.
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| Nucleic Acids Res 37(5):1701-12. Epub 2009 Jan 20. 2009
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| 12 | PNKP
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| Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination.
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| Karimi-Busheri F, Rasouli-Nia A, Allalunis-Turner J, Weinfeld M.
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| Cancer Res 67(14):6619-25. 2007
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| 13 | XRCC1, PNKP
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| XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates.
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| Mani RS, Fanta M, Karimi-Busheri F, Silver E, Virgen CA, Caldecott KW, Cass CE, Weinfeld M.
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| J Biol Chem 282(38):28004-13. Epub 2007 Jul 23. 2007
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| 14 | PNKP
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| Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway.
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| Audebert M, Salles B, Weinfeld M, Calsou P.
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| J Mol Biol 356(2):257-65. Epub 2005 Nov 28. 2006
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| 15 | PNKP
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| Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining.
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| Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M, West SC.
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| EMBO J 21(11):2827-32.PMID: 12032095 2002
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| 16 | PNKP, XRCC1
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| XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair.
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| Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW.
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| Cell 104(1):107-17. 2001
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| 17 | PNKP
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| Molecular characterization of a human DNA kinase.
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| Karimi-Busheri F, Daly G, Robins P, Canas B, Pappin DJ, Sgouros J, Miller GG, Fakhrai H, Davis EM, Le Beau MM, Weinfeld M.
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| J Biol Chem 274(34):24187-94 1999
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| 18 | PNKP
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| Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage.
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| Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW, Lasko DD.
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| J Biol Chem 274(34):24176-86 1999
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