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FLASH GENE

Symbol

UBE2V2

contributors: mct - updated : 21-10-2011

HGNC name	ubiquitin-conjugating enzyme E2 variant 2
HGNC id	12495

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q11.21      Physical location : 48.920.994 - 48.974.452
Synonym name	1 alpha,25-dihydroxyvitamin D3-inducible
	enterocyte differentiation promoting factor
	methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
Synonym symbol(s)	DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2

DNA

TYPE	functioning gene
STRUCTURE	53.46 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	cen - D8S519 - UBE2V2 - D8S517 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003350 4 - 1535 - 145 - 1998 9705497

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte

cell lineage
cell lines	some cancer lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an acidic domain
	a C terminal basic domain, lacking the critical cysteine residue essential for E2 catalytic activity

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	putatively involved in the control of differentiation
	ubiquitin dependent proteolytic protein
	UBE2V2 along with its heteromeric partner UBE2N can govern the error-free repair of DNA lesions by catalyzing the formation of lysine 63-linked polyubiquitin chains (K63-polyUb)
	serves a redundant role in human PCNA polyubiquitination

CELLULAR PROCESS	cell life, differentiation
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complexing with UBE2N (UBE2N-UBE2V2 is required for DNA damage repair but not nuclear factor kappaB (NF-kappaB) activation)

INTERACTION

DNA

RNA

small molecule

protein	UBE2V2 physical association with Ub is correlated with its ability to promote Lys63-linked Ub chain assembly (
	interactions between TRIM32 and UBE2V2, and UBE2V1
	UBE2N is the only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UBE2V1 or UBE2V2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS