motifs/domains
| a leucine-rich N-terminal half, which is likely to be involved in protein-protein interaction |
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N- terminus binds to the PDZ and kinase domains of LIMK1 and LIMK2  |
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a PX (Phox) domain, essential for association with phosphatidylinositol 3-phosphate-enriched endosomal membranes |
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four gelsolin-like repeats |
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15 LRR (leucine-rich) repeats |
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a C- terminal half which has high sequence similarity to gelsolin and is therefore likely to be involved in actin-binding |
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a sequence homolog to an acidic sequence of ryanodine receptors |
| basic FUNCTION
| may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components |
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regulates RAC1-dependent cell motility by interaction with and inhibition of the p21-activated kinase (PAK1) |
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in addition to regulating the PAK1 strand of RAC1 signaling, can also regulate other links in the web of RAC1 signaling pathways |
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having functions of enhancing cell survival, growth and migration |
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regulates cell migration by inhibiting p21-activated kinase (PAK1) |
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may be regulating cell invasion by negative modulation of the LIMK/cofilin pathway |
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nischarin small interfering RNA (siRNA) enhances cofilin phosphorylation, and may enhance random migration, resulting in stimulation of invasion |
