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FLASH GENE
Symbol NISCH contributors: mct - updated : 22-11-2010
HGNC name nischarin
HGNC id 18006
Location 3p21.1      Physical location : 52.489.523 - 52.527.087
Synonym name
  • imidazoline (dihydro-imidazole) receptor
  • I-1 receptor candidate protein
  • imidazoline receptor antisera selected
  • Synonym symbol(s) KIAA0975, FLJ14425, FLJ40413, FLJ90519, I-1, IRAS
    DNA
    TYPE functioning gene
    STRUCTURE 37.96 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 5252 166.6 1504 - 2000 10882231
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Lymphoid/Immunethymus   highly
     tonsils   highly
    Nervousbrain   highly
     spinal cord    
    Reproductivemale systemprostate  highly
     male systemtestis  highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text expressed both maternally and zygotically
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leucine-rich N-terminal half, which is likely to be involved in protein-protein interaction
  • N- terminus binds to the PDZ and kinase domains of LIMK1 and LIMK2
  • a PX (Phox) domain, essential for association with phosphatidylinositol 3-phosphate-enriched endosomal membranes
  • four gelsolin-like repeats
  • 15 LRR (leucine-rich) repeats
  • a C- terminal half which has high sequence similarity to gelsolin and is therefore likely to be involved in actin-binding
  • a sequence homolog to an acidic sequence of ryanodine receptors
  • HOMOLOGY
    interspecies homolog to C.elegans cosmid F13E9
    Homologene
    FAMILY
  • villin/gelsolin family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components
  • regulates RAC1-dependent cell motility by interaction with and inhibition of the p21-activated kinase (PAK1)
  • in addition to regulating the PAK1 strand of RAC1 signaling, can also regulate other links in the web of RAC1 signaling pathways
  • having functions of enhancing cell survival, growth and migration
  • regulates cell migration by inhibiting p21-activated kinase (PAK1)
  • may be regulating cell invasion by negative modulation of the LIMK/cofilin pathway
  • nischarin small interfering RNA (siRNA) enhances cofilin phosphorylation, and may enhance random migration, resulting in stimulation of invasion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IRS1, IRS2, IRS3
  • associates with LIMK1 and LIMK2 to inhibit LIMK activation, cofilin phosphorylation, and LIMK-mediated invasion of breast cancer cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate receptor for imidazolines
    Marker
    Therapy target proposed target for drug action relevant to blood pressure and glucose control
    ANIMAL & CELL MODELS