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| Dnmt3a(-/-) mice fail to establish maternal methylation imprints  | |
disruption of Dnmt3a in female mouse germ cells, with its preservation in somatic cells mutant leads to death in utero and the lack of methylation and allele-specific expression at maternally imprinted loci |
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Dnmt3a conditional mutant males show impairment of spermatogenesis and lack methylation at two of three paternally imprinted loci in spermatogonia |
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conditional mutant mice lacking Dnmt1 and Dnmt3 in forebrain excitatory neurons have abnormal long-term plasticity in the hippocampal CA1 region with deficits in learning and memory |
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Dnmt3a-deficient mice had more grade 2 and grade 3 lung tumors than WT mice |
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Pml-Rara requires Dnmt3a to initiate acute promyelocytic leukemia (APL) in mice |