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FLASH GENE
Symbol DNMT3A contributors: shn/mct - updated : 01-06-2016
HGNC name DNA (cytosine-5-)-methyltransferase 3 alpha
HGNC id 2978
ANIMAL & CELL MODELS
  • Dnmt3a(-/-) mice fail to establish maternal methylation imprints
  • disruption of Dnmt3a in female mouse germ cells, with its preservation in somatic cells mutant leads to death in utero and the lack of methylation and allele-specific expression at maternally imprinted loci
  • Dnmt3a conditional mutant males show impairment of spermatogenesis and lack methylation at two of three paternally imprinted loci in spermatogonia
  • conditional mutant mice lacking Dnmt1 and Dnmt3 in forebrain excitatory neurons have abnormal long-term plasticity in the hippocampal CA1 region with deficits in learning and memory
  • Dnmt3a-deficient mice had more grade 2 and grade 3 lung tumors than WT mice
  • Pml-Rara requires Dnmt3a to initiate acute promyelocytic leukemia (APL) in mice