motifs/domains
| DNA-binding activity of the N-terminal domain contributes to the DNA-methyltransferase activity via anchoring of the whole molecule to DNA under physiological salt conditions  |
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cytosine-5 methyltransferase motifs |
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central cysteine-rich region with homology to ATRX (XNP) |
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five C terminal conserved catalytic domains |
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a long N-terminal regulatory region with a PWWP domain |
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a chromatin/chromosome-targeting module |
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a Tudor-like motif, involved in the protein-protein interaction between DNMT3A and PRMT5 |
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a C-terminal domain responsible for the catalytic activity |
SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,nucleosome
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| intracellular,nucleus,chromatin/chromosome,euchromosome
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| intracellular,nucleus,chromatin/chromosome,heterochromosome
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| text
| almost all of the cellular contents of DNMT3A/3B, but not DNMT1, are strongly anchored to a subset of nucleosomes |
| basic FUNCTION
| essential for de novo DNA methylation and development |
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required for methylation of most imprinted loci in germ cells |
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upregulation of DNMT3A and TSIX implicated in delayed reprogramming of XIST/reactivation of inactive X chromosome after cell fusion |
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both a reader and a writer of repressive epigenetic marks, thereby directly linking histone and DNA methylation in gene silencing |
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mediate transcriptional repression |
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required for synaptic plasticity, learning and memory through their overlapping roles in maintaining DNA methylation and modulating neuronal gene expression in adult CNS neurons |
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required for neurogenesis and may be used for maintaining active chromatin states of genes critical for development |
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Dnmt3a activity in nucleus accumbens is necessary for cocaine-induced increases in dendritic spine density selectively for the thin type of spines |
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probably involved in the pathogenesis of acute promonocytic or monocytic leukemia in elderly individuals, whereas MLL abnormalities might be associated with acute monoblastic leukemia in relatively young individuals |
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may act like a tumor-suppressor gene in lung tumor progression and may be a critical determinant of lung cancer malignancy |
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is a critical participant in the epigenetic silencing of hematopoietic stem cell (HSC) regulatory genes, thereby enabling efficient differentiation |
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DNMT3A and DNMT3B, but not the maintenance enzyme DNMT1, are redox-dependent DNA dehydroxymethylase |
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is required for the establishment of normal methylation patterns |
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role of DNMT3A in maintaining DNA methylation patterns in cancer |
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is required for efficient maintenance methylation of active chromosome domains and DNMT3A-deficient tumors show moderate levels of gene deregulation in these domains |
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DNMT3A, DNMT3B, DNMT1 roles in Ca(2+) ion-dependent biological processes, including the genome-wide/local DNA demethylation during early embryogenesis, cell differentiation, neuronal activity-regulated gene expression, and carcinogenesis |
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STAT4 and DNMT3A play opposing roles in regulating Th1 gene expression, and one mechanism for STAT4-dependent gene programming is in establishing a derepressed genetic state susceptible to transactivation by additional fate-determining transcription factors |
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de novo DNA methylating enzyme DNMT3A in postmitotic neurons is necessary for normal memory formation and its function cannot be substituted by the maintenance DNA methylating enzyme DNMT1 |
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DNMT3A and DNMT3B have overlapping and distinct functions in hematopoietic stem cells |
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role for DNMT3A in the paraventricular nucleus of the hypothalamus (PVH) to link environmental conditions to altered energy homeostasis |
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regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway |
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DNMT3A and DNMT3B are critical to regulate the onset of IGK light chain rearrangement during early B-cell development |
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DNA dehydroxymethylation by DNMT3A, DNMT3B provides a simpler pathway to reduce DNA hydroxymethylation and methylation |
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moderates likely cognitive decline in subjects with mild cognitive impairment |
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DNMT3A and DNMT3B are primarily responsible for de novo methylation of specific cytosine residues in CpG dinucleotides during mammalian development |
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is important for enabling the activation of GBX2 expression, necessary for normal development of the inner ear |
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DNMT3A and METTL4 as the most relevant potential regulators of melanoma growth |
