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FLASH GENE
Symbol SIX6 contributors: - updated : 25-08-2005
HGNC name sine oculis homeobox homolog 6 (Drosophila)
HGNC id 10892
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six homeodomains
  • a helix-turn-helix DNA (homeo) binding domain
  • HOMOLOGY
    interspecies homolog to Drosophila sine oculis homeo box SIX6
    ortholog to murine Six6
    homolog to C.elegans ceh-32
    ortholog to chick Optx2
    Homologene
    FAMILY sine oculis (SIX/SINE) family of homeodomain transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION involved in eye development
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , cellular trafficking transport
    text histogenesis and organogenesis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BAPA , DEL14Q22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice deficient in the Six6 homeodomain factor (Li,2002)