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FLASH GENE
Symbol SIX6 contributors: - updated : 25-08-2005
HGNC name sine oculis homeobox homolog 6 (Drosophila)
HGNC id 10892
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
endocrinebraindiencephalonpituitary  
Nervousbraindiencephalonhypothalamus  
 nervecranial nerveoptic nerve  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte
Nervousoligodendrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text developing retina
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six homeodomains
  • a helix-turn-helix DNA (homeo) binding domain
    • HOMOLOGY
    interspecies homolog to Drosophila sine oculis homeo box SIX6
    ortholog to murine Six6
    homolog to C.elegans ceh-32
    ortholog to chick Optx2
    Homologene
    FAMILY sine oculis (SIX/SINE) family of homeodomain transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION involved in eye development
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , cellular trafficking transport
    text histogenesis and organogenesis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BAPA , DEL14Q22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice deficient in the Six6 homeodomain factor (Li,2002)