| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
|
|
on T cells (enhancement of cell-cell interaction through LFA1 and ICAM1) |
| tumoral
|
|
| --low
|
|
|
in several types of cancer (in cervical carcinoma), in metastatic progression |
| tumoral
|
| deletion
|
|
|
|
in prostate cancer with metastasis |
| tumoral
|
|
| --over
|
|
|
in non-small cell lung carcinoma cells suppresses the tumor invasiveness and metastatic potential by inducing MMP9 inactivation via the up-regulation of TIMP1 |
| constitutional
|
|
| --over
|
|
in ischemic tissues, suggesting that it is a hypoxia target gene ( |
| tumoral
|
|
| --low
|
|
|
in melanoma cell lines is related to LOH or allelic imbalance, but not to methylation of CD82 gene region |
| constitutional
|
|
| --over
|
|
|
may also cause alterations in extracellular matrix-binding integrin, and also may support the pathologic angiogenesis of CD151 |
