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FLASH GENE
Symbol CD82 contributors: mct/ - updated : 19-11-2016
HGNC name CD82 molecule
HGNC id 6210
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
on T cells (enhancement of cell-cell interaction through LFA1 and ICAM1)
tumoral     --low  
in several types of cancer (in cervical carcinoma), in metastatic progression
tumoral   deletion    
in prostate cancer with metastasis
tumoral     --over  
in non-small cell lung carcinoma cells suppresses the tumor invasiveness and metastatic potential by inducing MMP9 inactivation via the up-regulation of TIMP1
constitutional     --over  
in ischemic tissues, suggesting that it is a hypoxia target gene (
tumoral     --low  
in melanoma cell lines is related to LOH or allelic imbalance, but not to methylation of CD82 gene region
constitutional     --over  
may also cause alterations in extracellular matrix-binding integrin, and also may support the pathologic angiogenesis of CD151
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancermetastases 
targeting as a therapeutic approach for the treatment of a variety of metastatic cancers
cancerhemopathy 
CD82 and BCL2L12 may be promising therapeutic targets in AML
ANIMAL & CELL MODELS