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FLASH GENE

Symbol

AXL

contributors: mct/npt/pgu - updated : 25-01-2016

HGNC name	AXL receptor tyrosine kinase
HGNC id	905

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   myelogenous leukemia tumoral     --over   lung carcinoma, invasion and progression tumoral     --over   colon carcinoma tumoral     --over   melanoma tumoral     --over   in both glioma and vascular cells and predict poor prognosis in glioblastoma multiformis patients tumoral     --over   in breast cancer independently predicts poor overall patient survival tumoral   amplification     in mesotheliomas tumoral     --over   in triple-negative/basal B cell lines of breast cancer compared with luminal or basal A cell lines constitutional     --over   myocardial expression and serum concentration of AXL is elevated in heart failure patients compared to controls constitutional     --over   plasma soluble AXL concentrations were higher in the preeclampsia patients, and plasma soluble AXL levels were correlated with the clinical parameters of severe preeclampsia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	role of soluble AXL as a marker for NF1 related tumor burden
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma specific targeting of the Axl/Gas6 signaling pathway may represent a potential new approach for glioma treatment cancer angiogenesis   additive effect of AXL inhibition with anti-VEGF suggests that blocking AXL function might be a useful approach for enhancing antiangiogenic therapy and warrant further investigation cancer reproductive breast detection and targeted treatment of AXL-expressing tumors represents an important new therapeutic strategy for breast cancer cancer hemopathy   unique target for chronic lymphocytic leukemia treatment cancer digestive liver potential therapeutic target for hepatocellular carcinoma cancer endocrine thyroid TYRO3/AXL-GAS6 autocrine circuit sustains the malignant features of thyroid cancer cells and targeting the circuit could offer a novel therapeutic approach in this cancer cancer lung   AXL inhibition suppressed mesothelioma anchorage-independent growth cancer endocrine pancreas GAS6 inhibition with low-dose warfarin or other AXL-targeting agents may improve outcome in patients with AXL-expressing tumors cancer reproductive prostate role for AXL in prostate cancer tumorigenesis with implications for prostate cancer treatment

ANIMAL & CELL MODELS

Axl /Tyro3 null mice have delayed first estrus and abnormal cyclicity due to developmental defects in GnRH neuron migration and survival