1 | ARL2, AXL
|
| ARL2 overexpression inhibits glioma proliferation and tumorigenicity via down-regulating AXL.
|
| Wang Y, Guan G, Cheng W, Jiang Y, Shan F, Wu A, Cheng P, Guo Z.
|
| BMC Cancer 18(1):599. doi: 10.1186/s12885-018-4517-0.
2018
|
2 | AXL, GAS6
|
| Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis.
|
| Kirane A, Ludwig KF, Sorrelle N, Haaland G, Sandal T, Ranaweera R, Toombs JE, Wang M, Dineen SP, Micklem D, Dellinger MT, Lorens JB, Brekken RA.
|
| Cancer Res 75(18):3699-705. doi: 10.1158/0008-5472.CAN-14-2887-T. Epub 2015 Jul 23.
2015
|
3 | AXL, ELMO2
|
| Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.
|
| Abu-Thuraia A, Gauthier R, Chidiac R, Fukui Y, Screaton RA, Gratton JP, Côté JF.
|
| Mol Cell Biol 35(1):76-87. doi: 10.1128/MCB.00764-14. Epub 2014 Oct 20.
2015
|
4 | AXL, YWHAZ
|
| Axl activates autocrine transforming growth factor-β signaling in hepatocellular carcinoma.
|
| Reichl P, Dengler M, van Zijl F, Huber H, Führlinger G, Reichel C, Sieghart W, Peck-Radosavljevic M, Grubinger M, Mikulits W.
|
| Hepatology 61(3):930-41. doi: 10.1002/hep.27492. Epub 2015 Jan 28.
2015
|
5 | AXL
|
| Soluble AXL: a possible circulating biomarker for neurofibromatosis type 1 related tumor burden.
|
| Johansson G, Peng PC, Huang PY, Chien HF, Hua KT, Kuo ML, Chen CT, Lee MJ.
|
| PLoS One 9(12):e115916. doi: 10.1371/journal.pone.0115916. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119975.
2014
|
6 | AXL
|
| Axl receptor tyrosine kinase expression in breast cancer.
|
| D'Alfonso TM, Hannah J, Chen Z, Liu Y, Zhou P, Shin SJ.
|
| J Clin Pathol 67(8):690-6. doi: 10.1136/jclinpath-2013-202161. Epub 2014 Jun 5.
2014
|
7 | AXL
|
| AXL receptor tyrosine kinase is increased in patients with heart failure.
|
| Batlle M, Recarte-Pelz P, Roig E, Castel MA, Cardona M, Farrero M, Ortiz JT, Campos B, Pulgarín MJ, Ramírez J, Pérez-Villa F, García de Frutos P.
|
| Int J Cardiol 173(3):402-9. doi: 10.1016/j.ijcard.2014.03.016. Epub 2014 Mar 15.
2014
|
8 | AXL
|
| Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism.
|
| Salian-Mehta S, Xu M, Knox AJ, Plummer L, Slavov D, Taylor M, Bevers S, Hodges RS, Crowley WF Jr, Wierman ME.
|
| J Clin Endocrinol Metab 99(4):1452-60. doi: 10.1210/jc.2013-3426. Epub 2014 Jan 29.
2014
|
9 | AXL
|
| Plasma concentrations of sAxl are associated with severe preeclampsia.
|
| Liu X, Gong Y, Jia J, Bai Y, Gui S, Wang T, Zhou R.
|
| Clin Biochem 47(3):173-6. doi: 10.1016/j.clinbiochem.2013.11.001. Epub 2013 Nov 12.
2014
|
10 | AXL
|
| Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency.
|
| Son MY, Seol B, Han YM, Cho YS.
|
| Hum Mol Genet 23(7):1802-16. doi: 10.1093/hmg/ddt571. Epub 2013 Nov 11.
2014
|
11 | AXL
|
| Role of Axl in early kidney inflammation and progression of salt-dependent hypertension.
|
| Batchu SN, Hughson A, Gerloff J, Fowell DJ, Korshunov VA.
|
| Hypertension 62(2):302-9. doi: 10.1161/HYPERTENSIONAHA.113.01382. Epub 2013 Jun 17.
2013
|
12 | AXL
|
| The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.
|
| Paccez JD, Vasques GJ, Correa RG, Vasconcellos JF, Duncan K, Gu X, Bhasin M, Libermann TA, Zerbini LF.
|
| Oncogene 32(6):689-98. doi: 10.1038/onc.2012.89. Epub 2012 Mar 12.
2013
|
13 | AXL, TGFB1
|
| Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
|
| Bauer T, Zagórska A, Jurkin J, Yasmin N, Köffel R, Richter S, Gesslbauer B, Lemke G, Strobl H.
|
| J Exp Med 209(11):2033-47. doi: 10.1084/jem.20120493. Epub 2012 Oct 15.
2012
|
14 | AXL
|
| Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening.
|
| Gerloff J, Korshunov VA.
|
| Am J Pathol 180(5):2134-43. doi: 10.1016/j.ajpath.2012.01.036.
2012
|
15 | AXL
|
| The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy.
|
| Ghosh AK, Secreto C, Boysen J, Sassoon T, Shanafelt TD, Mukhopadhyay D, Kay NE.
|
| Blood 117(6):1928-37. Epub 2010 Dec 6.
2011
|
16 | AXL, YAP1
|
| AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma.
|
| Xu MZ, Chan SW, Liu AM, Wong KF, Fan ST, Chen J, Poon RT, Zender L, Lowe SW, Hong W, Luk JM.
|
| Oncogene 30(10):1229-40. Epub 2010 Nov 15.
2011
|
17 | AXL, GAS6, TYRO3
|
| Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancer.
|
| Avilla E, Guarino V, Visciano C, Liotti F, Svelto M, Krishnamoorthy G, Franco R, Melillo RM.
|
| Cancer Res 71(5):1792-804. Epub 2011 Feb 22.
2011
|
18 | AXL
|
| AXL regulates mesothelioma proliferation and invasiveness.
|
| Ou WB, Corson JM, Flynn DL, Lu WP, Wise SC, Bueno R, Sugarbaker DJ, Fletcher JA.
|
| Oncogene 30(14):1643-52. Epub 2010 Dec 6.
2011
|
19 | AXL
|
| Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.
|
| Gjerdrum C, Tiron C, Høiby T, Stefansson I, Haugen H, Sandal T, Collett K, Li S, McCormack E, Gjertsen BT, Micklem DR, Akslen LA, Glackin C, Lorens JB.
|
| Proc Natl Acad Sci U S A 107(3):1124-9. Epub 2009 Dec 28.PMID: 20080645 2010
|
20 | AXL, MZF1
|
| Myeloid zinc finger 1 induces migration, invasion, and in vivo metastasis through Axl gene expression in solid cancer.
|
| Mudduluru G, Vajkoczy P, Allgayer H.
|
| Mol Cancer Res 8(2):159-69. Epub 2010 Feb 9.PMID: 20145042 2010
|
21 | AXL, MERTK, TUB, TULP1, TYRO3
|
| Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.
|
| Caberoy NB, Zhou Y, Li W.
|
| EMBO J 29(23):3898-910. Epub 2010 Oct 26.
2010
|
22 | AXL, GAS6
|
| Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood.
|
| Ekman C, Stenhoff J, Dahlbäck B.
|
| J Thromb Haemost 8(4):838-44. doi: 10.1111/j.1538-7836.2010.03752.x. Epub 2010 Jan 17.
2010
|
23 | AXL, GAS6
|
| The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development.
|
| Park IK, Giovenzana C, Hughes TL, Yu J, Trotta R, Caligiuri MA.
|
| Blood 113(11):2470-7. Epub 2008 Oct 7.
2009
|
24 | AXL, GAS6
|
| Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis.
|
| Li Y, Ye X, Tan C, Hongo JA, Zha J, Liu J, Kallop D, Ludlam MJ, Pei L.
|
| Oncogene 28(39):3442-55. Epub 2009 Jul 27.PMID: 1963368 2009
|
25 | AXL, GAS6
|
| Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
|
| Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M.
|
| J Immunol 183(5):3004-13. Epub 2009 Aug 5.PMID: 19657094 2009
|
26 | AXL, TNK2
|
| Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.
|
| Pao-Chun L, Chan PM, Chan W, Manser E.
|
| J Biol Chem 284(50):34954-63. doi: 10.1074/jbc.M109.072660. Epub 2009 Oct 8.
2009
|
27 | AXL, GAS6
|
| Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme.
|
| Hutterer M, Knyazev P, Abate A, Reschke M, Maier H, Stefanova N, Knyazeva T, Barbieri V, Reindl M, Muigg A, Kostron H, Stockhammer G, Ullrich A.
|
| Clin Cancer Res 14(1):130-8.
2008
|
28 | AXL
|
| Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.
|
| Tai KY, Shieh YS, Lee CS, Shiah SG, Wu CW.
|
| Oncogene 27(29):4044-55. Epub 2008 Mar 17.
2008
|
29 | AXL, MERTK, TYRO3
|
| The role of Tyro 3 subfamily receptors in the regulation of hemostasis and megakaryocytopoiesis.
|
| Wang H, Chen S, Chen Y, Wang H, Wu H, Tang H, Xiong W, Ma J, Ge Y, Lu Q, Han D.
|
| Haematologica 92(5):643-50.
2007
|
30 | AXL, GAS6
|
| Structural basis for Gas6-Axl signalling.
|
| Sasaki T, Knyazev PG, Clout NJ, Cheburkin Y, Gohring W, Ullrich A, Timpl R, Hohenester E.
|
| EMBO J 25(1):80-7. Epub 2005 Dec 15. 2006
|
31 | AXL, RANBP9, TYRO3
|
| The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases.
|
| Hafizi S, Gustafsson A, Stenhoff J, Dahlback B.
|
| Int J Biochem Cell Biol 37(11):2344-56. 2005
|
32 | AXL
|
| Expression of axl in lung adenocarcinoma and correlation with tumor progression.
|
| Shieh YS, Lai CY, Kao YR, Shiah SG, Chu YW, Lee HS, Wu CW.
|
| Neoplasia 7(12):1058-64. 2005
|
33 | AXL, GAS6, MERTK, TYRO3
|
| Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.
|
| Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA.
|
| J Thromb Haemost 3(4):733-41. Epub 2005 Feb 23. 2005
|
34 | AXL, GAS6
|
| Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells.
|
| Hasanbasic I, Cuerquis J, Varnum B, Blostein MD.
|
| Am J Physiol Heart Circ Physiol 287(3):H1207-13. Epub 2004 May 6. 2004
|
35 | AXL, GAS6
|
| Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.
|
| Allen MP, et al.
|
| Mol Endocrinol 13(2):191-201. 1999
|
36 | AXL, SHBG, TYRO3
|
| Tyro-3 family receptors are essential regulators of mammalian spermatogenesis.
|
| Lu Q, et al.
|
| Nature 398(6729):723-8. 1999
|
37 | PROS1, AXL, TYRO3, GAS6
|
| The anticoagulation factor protein S and its relative, Gas6, are ligandsfor the Tyro 3/Axl family of receptor tyrosine kinases.
|
| Stitt TN, et al.
|
| Cell 80 : 661-670. 1995
|
38 | AXL
|
| A PvuII-polymorphism within the AXL gene on chromosome 19q13.1.
|
| Linz U, et al.
|
| Hum Mol Genet 2 : 492. 1993
|
39 | AXL
|
| A novel putative tyrosine kinase receptor with oncogenic potential.
|
| Janssen JWG, et al.
|
| Oncogene 6 : 2113-2120. 1991
|