Citations for
1ARL2, AXL
ARL2 overexpression inhibits glioma proliferation and tumorigenicity via down-regulating AXL.
Wang Y, Guan G, Cheng W, Jiang Y, Shan F, Wu A, Cheng P, Guo Z.
BMC Cancer 18(1):599. doi: 10.1186/s12885-018-4517-0. 2018
2AXL, GAS6
Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis.
Kirane A, Ludwig KF, Sorrelle N, Haaland G, Sandal T, Ranaweera R, Toombs JE, Wang M, Dineen SP, Micklem D, Dellinger MT, Lorens JB, Brekken RA.
Cancer Res 75(18):3699-705. doi: 10.1158/0008-5472.CAN-14-2887-T. Epub 2015 Jul 23. 2015
3AXL, ELMO2
Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.
Abu-Thuraia A, Gauthier R, Chidiac R, Fukui Y, Screaton RA, Gratton JP, Côté JF.
Mol Cell Biol 35(1):76-87. doi: 10.1128/MCB.00764-14. Epub 2014 Oct 20. 2015
4AXL, YWHAZ
Axl activates autocrine transforming growth factor-β signaling in hepatocellular carcinoma.
Reichl P, Dengler M, van Zijl F, Huber H, Führlinger G, Reichel C, Sieghart W, Peck-Radosavljevic M, Grubinger M, Mikulits W.
Hepatology 61(3):930-41. doi: 10.1002/hep.27492. Epub 2015 Jan 28. 2015
5AXL
Soluble AXL: a possible circulating biomarker for neurofibromatosis type 1 related tumor burden.
Johansson G, Peng PC, Huang PY, Chien HF, Hua KT, Kuo ML, Chen CT, Lee MJ.
PLoS One 9(12):e115916. doi: 10.1371/journal.pone.0115916. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119975. 2014
6AXL
Axl receptor tyrosine kinase expression in breast cancer.
D'Alfonso TM, Hannah J, Chen Z, Liu Y, Zhou P, Shin SJ.
J Clin Pathol 67(8):690-6. doi: 10.1136/jclinpath-2013-202161. Epub 2014 Jun 5. 2014
7AXL
AXL receptor tyrosine kinase is increased in patients with heart failure.
Batlle M, Recarte-Pelz P, Roig E, Castel MA, Cardona M, Farrero M, Ortiz JT, Campos B, Pulgarín MJ, Ramírez J, Pérez-Villa F, García de Frutos P.
Int J Cardiol 173(3):402-9. doi: 10.1016/j.ijcard.2014.03.016. Epub 2014 Mar 15. 2014
8AXL
Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism.
Salian-Mehta S, Xu M, Knox AJ, Plummer L, Slavov D, Taylor M, Bevers S, Hodges RS, Crowley WF Jr, Wierman ME.
J Clin Endocrinol Metab 99(4):1452-60. doi: 10.1210/jc.2013-3426. Epub 2014 Jan 29. 2014
9AXL
Plasma concentrations of sAxl are associated with severe preeclampsia.
Liu X, Gong Y, Jia J, Bai Y, Gui S, Wang T, Zhou R.
Clin Biochem 47(3):173-6. doi: 10.1016/j.clinbiochem.2013.11.001. Epub 2013 Nov 12. 2014
10AXL
Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency.
Son MY, Seol B, Han YM, Cho YS.
Hum Mol Genet 23(7):1802-16. doi: 10.1093/hmg/ddt571. Epub 2013 Nov 11. 2014
11AXL
Role of Axl in early kidney inflammation and progression of salt-dependent hypertension.
Batchu SN, Hughson A, Gerloff J, Fowell DJ, Korshunov VA.
Hypertension 62(2):302-9. doi: 10.1161/HYPERTENSIONAHA.113.01382. Epub 2013 Jun 17. 2013
12AXL
The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.
Paccez JD, Vasques GJ, Correa RG, Vasconcellos JF, Duncan K, Gu X, Bhasin M, Libermann TA, Zerbini LF.
Oncogene 32(6):689-98. doi: 10.1038/onc.2012.89. Epub 2012 Mar 12. 2013
13AXL, TGFB1
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
Bauer T, Zagórska A, Jurkin J, Yasmin N, Köffel R, Richter S, Gesslbauer B, Lemke G, Strobl H.
J Exp Med 209(11):2033-47. doi: 10.1084/jem.20120493. Epub 2012 Oct 15. 2012
14AXL
Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening.
Gerloff J, Korshunov VA.
Am J Pathol 180(5):2134-43. doi: 10.1016/j.ajpath.2012.01.036. 2012
15AXL
The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy.
Ghosh AK, Secreto C, Boysen J, Sassoon T, Shanafelt TD, Mukhopadhyay D, Kay NE.
Blood 117(6):1928-37. Epub 2010 Dec 6. 2011
16AXL, YAP1
AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma.
Xu MZ, Chan SW, Liu AM, Wong KF, Fan ST, Chen J, Poon RT, Zender L, Lowe SW, Hong W, Luk JM.
Oncogene 30(10):1229-40. Epub 2010 Nov 15. 2011
17AXL, GAS6, TYRO3
Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancer.
Avilla E, Guarino V, Visciano C, Liotti F, Svelto M, Krishnamoorthy G, Franco R, Melillo RM.
Cancer Res 71(5):1792-804. Epub 2011 Feb 22. 2011
18AXL
AXL regulates mesothelioma proliferation and invasiveness.
Ou WB, Corson JM, Flynn DL, Lu WP, Wise SC, Bueno R, Sugarbaker DJ, Fletcher JA.
Oncogene 30(14):1643-52. Epub 2010 Dec 6. 2011
19AXL
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.
Gjerdrum C, Tiron C, Høiby T, Stefansson I, Haugen H, Sandal T, Collett K, Li S, McCormack E, Gjertsen BT, Micklem DR, Akslen LA, Glackin C, Lorens JB.
Proc Natl Acad Sci U S A 107(3):1124-9. Epub 2009 Dec 28.PMID: 20080645 2010
20AXL, MZF1
Myeloid zinc finger 1 induces migration, invasion, and in vivo metastasis through Axl gene expression in solid cancer.
Mudduluru G, Vajkoczy P, Allgayer H.
Mol Cancer Res 8(2):159-69. Epub 2010 Feb 9.PMID: 20145042 2010
21AXL, MERTK, TUB, TULP1, TYRO3
Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.
Caberoy NB, Zhou Y, Li W.
EMBO J 29(23):3898-910. Epub 2010 Oct 26. 2010
22AXL, GAS6
Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood.
Ekman C, Stenhoff J, Dahlbäck B.
J Thromb Haemost 8(4):838-44. doi: 10.1111/j.1538-7836.2010.03752.x. Epub 2010 Jan 17. 2010
23AXL, GAS6
The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development.
Park IK, Giovenzana C, Hughes TL, Yu J, Trotta R, Caligiuri MA.
Blood 113(11):2470-7. Epub 2008 Oct 7. 2009
24AXL, GAS6
Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis.
Li Y, Ye X, Tan C, Hongo JA, Zha J, Liu J, Kallop D, Ludlam MJ, Pei L.
Oncogene 28(39):3442-55. Epub 2009 Jul 27.PMID: 1963368 2009
25AXL, GAS6
Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M.
J Immunol 183(5):3004-13. Epub 2009 Aug 5.PMID: 19657094 2009
26AXL, TNK2
Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.
Pao-Chun L, Chan PM, Chan W, Manser E.
J Biol Chem 284(50):34954-63. doi: 10.1074/jbc.M109.072660. Epub 2009 Oct 8. 2009
27AXL, GAS6
Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme.
Hutterer M, Knyazev P, Abate A, Reschke M, Maier H, Stefanova N, Knyazeva T, Barbieri V, Reindl M, Muigg A, Kostron H, Stockhammer G, Ullrich A.
Clin Cancer Res 14(1):130-8. 2008
28AXL
Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.
Tai KY, Shieh YS, Lee CS, Shiah SG, Wu CW.
Oncogene 27(29):4044-55. Epub 2008 Mar 17. 2008
29AXL, MERTK, TYRO3
The role of Tyro 3 subfamily receptors in the regulation of hemostasis and megakaryocytopoiesis.
Wang H, Chen S, Chen Y, Wang H, Wu H, Tang H, Xiong W, Ma J, Ge Y, Lu Q, Han D.
Haematologica 92(5):643-50. 2007
30AXL, GAS6
Structural basis for Gas6-Axl signalling.
Sasaki T, Knyazev PG, Clout NJ, Cheburkin Y, Gohring W, Ullrich A, Timpl R, Hohenester E.
EMBO J 25(1):80-7. Epub 2005 Dec 15. 2006
31AXL, RANBP9, TYRO3
The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases.
Hafizi S, Gustafsson A, Stenhoff J, Dahlback B.
Int J Biochem Cell Biol 37(11):2344-56. 2005
32AXL
Expression of axl in lung adenocarcinoma and correlation with tumor progression.
Shieh YS, Lai CY, Kao YR, Shiah SG, Chu YW, Lee HS, Wu CW.
Neoplasia 7(12):1058-64. 2005
33AXL, GAS6, MERTK, TYRO3
Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.
Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA.
J Thromb Haemost 3(4):733-41. Epub 2005 Feb 23. 2005
34AXL, GAS6
Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells.
Hasanbasic I, Cuerquis J, Varnum B, Blostein MD.
Am J Physiol Heart Circ Physiol 287(3):H1207-13. Epub 2004 May 6. 2004
35AXL, GAS6
Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.
Allen MP, et al.
Mol Endocrinol 13(2):191-201. 1999
36AXL, SHBG, TYRO3
Tyro-3 family receptors are essential regulators of mammalian spermatogenesis.
Lu Q, et al.
Nature 398(6729):723-8. 1999
37PROS1, AXL, TYRO3, GAS6
The anticoagulation factor protein S and its relative, Gas6, are ligandsfor the Tyro 3/Axl family of receptor tyrosine kinases.
Stitt TN, et al.
Cell 80 : 661-670. 1995
38AXL
A PvuII-polymorphism within the AXL gene on chromosome 19q13.1.
Linz U, et al.
Hum Mol Genet 2 : 492. 1993
39AXL
A novel putative tyrosine kinase receptor with oncogenic potential.
Janssen JWG, et al.
Oncogene 6 : 2113-2120. 1991