| basic FUNCTION
| mediating protein-protein interaction |
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essential for sperm flagellar motility and is important for the maintenance of the structural integrity of mature sperm |
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axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella  |
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SPAG6 not only regulates cilia/flagellar motility, but that in its absence, ciliogenesis, axoneme orientation, and tracheal epithelial cell polarity are altered |
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might have a role in malignant myeloid hematologic cell proliferation and apoptosis by regulating caspase proteins and TP53 |
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plays an important role in sperm flagellar function |
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is crucial for sperm motility |
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likely controlled neuronal migration as well as neurite branching and elongation |
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selectively increased expression of acetylated tubulin, a microtubule stability marker |
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new roles for SPAG6 in modulation of cell morphology, proliferation, migration, and ciliogenesis |
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plays an essential role in the process of neuronal proliferation and differentiation |
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SPAG6 and L1TD1 are tumor-specifically methylated in non-small cell lung cancer (NSCLC) and DNA methylation is involved in the transcriptional regulation of these genes |
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potential role of SPAG6 and SPAG16 stabilizing the cytoplasmic microtubules of eukaryotic cells |
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SPAG6 gene regulates tumor cell proliferation, apoptosis, invasion, and metastasis |
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likely SPAG6 gene could affect hearing by regulating the expression of SLC26A5 gene |
