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FLASH GENE

Symbol

ITGA11

contributors: mct - updated : 09-02-2018

HGNC name	integrin, alpha 11
HGNC id	6136

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive salivary gland       highly Reproductive female system uterus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal signal peptide,with large extracellular domain consisting of a sevenfold repeated structure (FG-GAP)
	an I domain, expressed in muscle tissue, with a metal ion-dependent adhesion site motif
	putative cation-binding motifs in the three of four C terminal repeats
	a single inserted between the second and third repeats ligand binding
	a single transmembrane segment (1TM) and a short non conserved cytoplasmic domain

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

integrin family

CATEGORY

adhesion , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
	is involved in the formation of myofibroblasts and fibroid development
	may be involved in attaching muscle tissue to the extracellular matrix
	decrease in ITGA11 is associated with its loss from focal adhesions
	might be involved in fibrogenic signaling and might act downstream of the hedgehog signaling pathway

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

likely dimerizing with ITGB1

INTERACTION

DNA

RNA

small molecule

protein	interferon stimulated gene
	interactions between ITGA11s and the Smad-dependent TGFB2 signalling may contribute to the formation of pro-fibrotic myofibroblasts and the development of a fibrotic interstitium in diabetic cardiomyopathy
	glycated collagen in the cardiac interstitium triggers an autocrine TGFB2 signaling pathway that stimulates ITGA expression through Smad2/3 binding elements in the ITGA promoter, which is important for myofibroblast formation and fibrosis
	FGF2 may be redirecting fibroblasts towards an anti-fibrotic phenotype by overriding TGFB1 mediated ITGA11 expression

cell & other

REGULATION

induced by

TGFB1, inducing alpha11 transcription in the fibrosarcoma cell line HT1080 as well as in primary fibroblasts

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non-small-cell lung carcinoma tumoral     --over   in head and neck squamous cell stroma and colocalized with ACTA2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS