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FLASH GENE
Symbol FUT6 contributors: mct - updated : 11-06-2020
HGNC name fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
HGNC id 4017
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY glycosyltransferase 10 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
text type II membrane protein
basic FUNCTION
  • glycosylation independent of Golgi associated glycosylation
  • catalyzing the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates
  • FUT6 is a key mediator of Prostate carcinoma cells trafficking to the bone marrow (BM)
  • FUT3/FUT6 has an essential role in cancer cell adhesion to endothelial cells by upregulation of sialyl Lewis antigens and also by enhancement of cancer cell migration through TGFB1-mediated EMT
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating SELPLG
  • FUT4-, FUT6- or FUT8-mediated multidrug resistance (MDR) in hepatocellular carcinoma is associated with the activation of the PI3K/Akt pathway and the expression of ABCC1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    altered expression of fucosylation pathway gene(FUT6), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)
    Susceptibility to intestinal-type gastric cancer
    Variant & Polymorphism other
  • variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 associated with intestinal-type gastric cancer
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    may serve as a viable drug target in preclinical tests of therapeutics for reduction of PCa bone metastasis
    ANIMAL & CELL MODELS