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FLASH GENE
Symbol FUT6 contributors: mct - updated : 11-06-2020
HGNC name fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
HGNC id 4017
Location 19p13.3      Physical location : 5.830.636 - 5.839.742
Synonym name FucT-VI
Synonym symbol(s) FCT3A6, FCT3A, FT1A, Fuc-TVI, FucT-VI
EC.number 2.4.1.65/ 2.4.1.152
DNA
TYPE functioning gene
STRUCTURE 9.61 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map pter - D19S209 - D19S216 - FUT6 - FUT3 - FUT5 - D19S367 - D19S406 - cen
Authors Reguigne-Arnould (95)
RNA
TRANSCRIPTS type messenger
text two splice variants in kidney, liver and one in weibel palate bodies of endothelial cells
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2642 - 359 - 2017 28334792
4 - 2616 - 359 - 2017 28334792
3 - 2488 - 359 - 2017 28334792
4 - 2613 - 359 - 2017 28334792
6 - 2598 - 357 - 2017 28334792
4 - 2461 - 359 - 2017 28334792
4 - 2300 - 357 - 2017 28334792
3 - 2416 - 359 - 2017 28334792
2 - 2288 - 359 - 2017 28334792
3 - 2172 - 357 - 2017 28334792
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
 stomach   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY glycosyltransferase 10 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
text type II membrane protein
basic FUNCTION
  • glycosylation independent of Golgi associated glycosylation
  • catalyzing the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates
  • FUT6 is a key mediator of Prostate carcinoma cells trafficking to the bone marrow (BM)
  • FUT3/FUT6 has an essential role in cancer cell adhesion to endothelial cells by upregulation of sialyl Lewis antigens and also by enhancement of cancer cell migration through TGFB1-mediated EMT
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating SELPLG
  • FUT4-, FUT6- or FUT8-mediated multidrug resistance (MDR) in hepatocellular carcinoma is associated with the activation of the PI3K/Akt pathway and the expression of ABCC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    altered expression of fucosylation pathway gene(FUT6), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)
    Susceptibility to intestinal-type gastric cancer
    Variant & Polymorphism other
  • variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 associated with intestinal-type gastric cancer
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    may serve as a viable drug target in preclinical tests of therapeutics for reduction of PCa bone metastasis
    ANIMAL & CELL MODELS