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FLASH GENE

Symbol

FUT6

contributors: mct - updated : 11-06-2020

HGNC name	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
HGNC id	4017

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	9.61 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	pter - D19S209 - D19S216 - FUT6 - FUT3 - FUT5 - D19S367 - D19S406 - cen
Authors	Reguigne-Arnould (95)

RNA

TRANSCRIPTS	type	messenger

text	two splice variants in kidney, liver and one in weibel palate bodies of endothelial cells

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001369505 4 - 2642 NP_001356434 - 359 - 2017 28334792 NM_001369504 4 - 2616 NP_001356433 - 359 - 2017 28334792 NM_001381955 3 - 2488 NP_001368884 - 359 - 2017 28334792 NM_001381956 4 - 2613 NP_001368885 - 359 - 2017 28334792 NM_001381958 6 - 2598 NP_001368887 - 357 - 2017 28334792 NM_001369502 4 - 2461 NP_001356431 - 359 - 2017 28334792 NM_001381959 4 - 2300 NP_001368888 - 357 - 2017 28334792 NM_000150 3 - 2416 NP_000141 - 359 - 2017 28334792 NM_001040701 2 - 2288 NP_001035791 - 359 - 2017 28334792 NM_001381957 3 - 2172 NP_001368886 - 357 - 2017 28334792

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly   stomach       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

glycosyltransferase 10 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein

basic FUNCTION	glycosylation independent of Golgi associated glycosylation
	catalyzing the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates
	FUT6 is a key mediator of Prostate carcinoma cells trafficking to the bone marrow (BM)
	FUT3/FUT6 has an essential role in cancer cell adhesion to endothelial cells by upregulation of sialyl Lewis antigens and also by enhancement of cancer cell migration through TGFB1-mediated EMT

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	activating SELPLG
	FUT4-, FUT6- or FUT8-mediated multidrug resistance (MDR) in hepatocellular carcinoma is associated with the activation of the PI3K/Akt pathway and the expression of ABCC1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   altered expression of fucosylation pathway gene(FUT6), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)

Susceptibility

to intestinal-type gastric cancer

Variant & Polymorphism other	variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 associated with intestinal-type gastric cancer

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate may serve as a viable drug target in preclinical tests of therapeutics for reduction of PCa bone metastasis

ANIMAL & CELL MODELS