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FLASH GENE
Symbol PLA2G7 contributors: mct/npt - updated : 14-06-2008
HGNC name phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
HGNC id 9040
Location 6p21.2-p12      Physical location : 46.672.053 - 46.703.430
Synonym name
  • platelet-activating factor acetylhydrolase
  • PAF 2-acylhydrolase
  • LDL-associated phospholipase A2
  • 2-acetyl-1-alkylglycerophosphocholine esterase
  • Synonym symbol(s) PAFAH, LDL-PLA2, LDL-PLA
    EC.number 3.1.1.47
    DNA
    TYPE functioning gene
    STRUCTURE 30.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1880 - 440 - Sutton (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
     pharynx   highly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemplacenta  highly
     male systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a unique sequence motif Gly-X-Ser-X-Gly commonly found in lipases
  • HOMOLOGY
    Homologene
    FAMILY
  • AB hydrolase superfamily
  • lipase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • LDL-associated phospholipase A2 group VII, serine dependent, involved in the oxidative modification of low density lipoproteins
  • platelet activating factor acetylhydrolase plasma
  • inhibiting the proinflammatory properties of PAH
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with high and low density lipoproteins (HDL and LDL)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • mutations V279 are a risk factor for stroke in Japanese population
  • suceptibility to atopy and asthma
  • to coronary artery disease
  • Variant & Polymorphism SNP , other
  • I198T
  • A379V protecting against coronary artery disease
  • alleles thr-198 and val-379 are associated with atopy and asthma
  • SNP increasing the risk of coronary artery disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS