Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | WASHC5 | contributors: mct/shn - updated : 31-03-2021 |
HGNC name | WASH complex subunit 5 |
HGNC id | 28984 |
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Corresponding disease |
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Location | 8q24.13 Physical location : - | ||
Synonym name | |||
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Synonym symbol(s) | MGC111053, SPG8, KIAA0196, RTSC, RTSC1 |
DNA |
TYPE | functioning gene |
STRUCTURE | 67.56 kb 29 Exon(s) |
MAPPING | cloned | Y | linked | N | status | provisional |
Map | cen - D8S1832 - D8S1799 - KIAA0196 - D8S266 - D1S460 - qter |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains |
secondary structure | two helices from the 1,159-aa protein are shown, including amino acids 614-634 in one -helix and amino acids 662-672 from a nearby -helix in the antiparallel direction |
HOMOLOGY |
interspecies | ortholog to KIAA0196, Pan troglodytes |
Homologene |
FAMILY |
CATEGORY | regulatory |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,endoplasmic reticulum | |
intracellular,cytoplasm,organelle,endosome | |
intracellular,cytoplasm,cytosolic | |
intracellular,nucleus,nucleoplasm | |
text | |
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basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling | signal transduction |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | SPG8 , RSTC1 |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |
Morpholino oligonucleotide knockdown of the KIAA0196 protein ortholog in zebrafish resulted in an enlarged heart cavity, along with a curly-tail phenotype that severely impaired the ability of the fish to swim properly | |
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