| basic FUNCTION
| involved in the complex network of protein governing response to retinoic acid and its metabolites |
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playing an important role in the control of drug metabolism and disposition |
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key transcription factor regulating phenobarbital (PB)-inducible transcription of various hepatic genes that encode xenobiotic/steroid-metabolizing enzymes  |
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regulates serum triglyceride levels under conditions of metabolic stress |
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its activation improves type 2 diabetes, and that these actions of CAR suggest therapeutic approaches to the disease |
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plays a key role in the expression of xenobiotic/steroid and drug metabolizing enzymes and their transporters |
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able to modulate the metabolic fate of glucose, lipids, and bile acids, and it is also involved in cell-cell communication, regulation of the cell cycle, and chemical carcinogenesis |
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critical xenobiotic sensor that regulates xenobiotic metabolism, drug clearance, energy and lipid homoeostasis, cell proliferation and development. |
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role for NR1I3 in hepatic lineage commitment |
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plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through modulating the transcription of its numerous target genes |
