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FLASH GENE

Symbol

NR1I3

contributors: mct - updated : 22-08-2015

HGNC name	nuclear receptor subfamily 1, group I, member 3
HGNC id	7969

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.98 kb     9 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	cen - DXS983 - DXS8079 - NR1I3 - PGK1 - DXS1002 - DXS995 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001077479 8 - 1247 NP_001070947 - 319 - 2013 23378627 SV-22 NM_001077470 7 - 1130 NP_001070938 - 280 - 2013 23378627 SV-3 NM_001077475 7 - 976 NP_001070943 - 267 - 2013 23378627 SV-11 NM_001077477 8 - 1093 NP_001070945 - 306 - 2013 23378627 SV-13 NM_001077476 8 - 1108 NP_001070944 - 311 - 2013 23378627 SV-12 NM_001077472 8 - 1262 NP_001070940 - 324 - 2013 23378627 SV-6 NM_001077473 8 - 1120 NP_001070941 - 315 - 2013 23378627 SV-7 NM_001077474 8 - 1116 NP_001070942 - 296 - 2013 23378627 SV-8 NM_001077471 8 - 1270 NP_001070939 - 309 - 2013 23378627 SV-5 or CAR3 NM_001077481 8 - 1285 NP_001070949 - 314 - 2013 23378627 NM_005122 9 - 1387 NP_005113 - 348 - 2013 23378627 WT or REF NM_001077478 9 - 1245 NP_001070946 - 339 - 2013 23378627 SV-14 NM_001077480 9 - 1399 NP_001070948 - 352 - 2013 23378627 NM_001077482 9 - 1414 NP_001070950 - 357 - 2013 23378627 SV-25 or CAR2 NM_001077469 - - 1248 NP_001070937 - 340 - 2013 23378627 SV-1

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver       predominantly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	DNA binding domain proximal P box followed by a ligand binding domain
	short N terminal domain followed by the DNA binding and ligand binding/dimerization domains
	C4 zinc finger domain

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Nr1l3

Homologene

FAMILY

nuclear receptor subfamily 1, group I

CATEGORY

transcription factor , receptor nuclear

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus,nucleoplasm
text	is retained in the cytoplasm of noninduced livers and translocates into the nucleus after Phenobarbital induction

basic FUNCTION	involved in the complex network of protein governing response to retinoic acid and its metabolites
	playing an important role in the control of drug metabolism and disposition
	key transcription factor regulating phenobarbital (PB)-inducible transcription of various hepatic genes that encode xenobiotic/steroid-metabolizing enzymes
	regulates serum triglyceride levels under conditions of metabolic stress
	its activation improves type 2 diabetes, and that these actions of CAR suggest therapeutic approaches to the disease
	plays a key role in the expression of xenobiotic/steroid and drug metabolizing enzymes and their transporters
	able to modulate the metabolic fate of glucose, lipids, and bile acids, and it is also involved in cell-cell communication, regulation of the cell cycle, and chemical carcinogenesis
	critical xenobiotic sensor that regulates xenobiotic metabolism, drug clearance, energy and lipid homoeostasis, cell proliferation and development.
	role for NR1I3 in hepatic lineage commitment
	plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through modulating the transcription of its numerous target genes

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

androgen receptor

a component	putatively heterodimerizing with RXR(s)
	DNAJC7 directly interacts with the ligand-binding domain of NR1I3 and mediates the formation of a cytoplasmic NR1I3-DNAJC7-HSP90 ternary complex

INTERACTION

DNA

RNA

small molecule

protein	NR0B1 is a novel and potent NR1I3 corepressor, suggesting that NR0B1 functions as a coordinate hepatic regulator of NR1I3 biological function
	DDX54 is a novel NR1I3-interacting protein
	interaction with PSMC5 (suppressor for Gal1), a subunit of the 26S proteasome
	ubiquitin-proteasomal regulation of DNAJC7 and HSPA4 are important contributors to the regulation of cytoplasmic NR1I3 levels
	CCAR1 is a novel transcriptional cofactor for NR1I3
	CCAR1 can act as an enhancer-dependent coactivator of NR1I3 1)

cell & other

REGULATION

induced by

dexamethasone

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS