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FLASH GENE

Symbol

ADAMTS1

contributors: mct - updated : 25-09-2018

HGNC name	ADAM metallopeptidase with thrombospondin type 1 motif, 1
HGNC id	217

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   associated with various inflammatory processes as well as development of cancer cachexia constitutional     --over   in brain of patients with neurodegenerative disease leading to or reflecting pathological lesions in Down syndrome tumoral       loss of function ADAMTS1 gene inactivated through promoter hypermethylation in colorectal tumor development       --over   strongly expressed in myocardial infarction (Hatipoglu 2009) tumoral     --over   promotes pulmonary metastasis of TA3 mammary carcinoma (Lu 2009) tumoral     --low   by aberrant methylation of ADAMTS1 in non-small cell lung cancer (Choi 2008) constitutional     --low   in the maternal and cord blood were lower in the preeclampsia group than in the control group

Susceptibility

Variant & Polymorphism

Candidate gene	may be used as marker protein for neurodegeneration
	molecular targeting of MMP1 and ADAMTS1, combined with inhibition of EGFR, may potentially reduce the risk of bone metastasis for a significant number of breast cancer patients (Lu 2009)
Marker	methylation status of ADAMTS1 and BNC1 in cfDNA shows promise for detecting pancreatic cancer during the early stages when curative resection of the tumor is still possible
Therapy target

ANIMAL & CELL MODELS