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FLASH GENE

Symbol

ATG5

contributors: mct/ - updated : 24-10-2018

HGNC name	ATG5 autophagy related 5 homolog (S. cerevisiae)
HGNC id	589

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCAR25

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     led to increased mitochondrial mass in peripheral T cells constitutional     --over   in autoimmune demyelination and multiple sclerosis tumoral somatic mutation       in gastric and colorectal cancers with microsatellite instability

Susceptibility

to development of hepatocellular carcinoma (HCC)

Variant & Polymorphism other	ATG5 rs17067724 significantly associated with HCC risk

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed obesity     ATF4/ATG5 axis in the hypothalamus may be a new potential therapeutic target for treating obesity and obesity-related metabolic diseases

ANIMAL & CELL MODELS

	All Atg5-null mice died within 1 day of delivery, the survival time of starved Atg5-deficient neonates (approximately 12 hours) was much shorter than that of wildtype mice (approximately 21 hours). Atg5-deficient neonates exhibited reduced amino acid concentrations in plasma and tissues and displayed signs of energy depletion. Neonates adapt to immediate post-birth starvation by inducing autophagy
	mice deficient for Atg5 or Atg7 specifically in the dopaminergic neurons were less sensitive to developing a morphine reward response, behavioral sensitization, analgesic tolerance and physical dependence compared to wild-type mice
	Atg5-deficient mice displayed abnormal Tbx2 expression and defects in valve development and chamber septation