| basic FUNCTION
| involved in platelet activation and agregation |
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integral membrane proteins that facilitate the organization of membrane and intracellular signaling molecules into dynamic signaling microdomains, tetraspanin-enriched microdomains (TEMs)  |
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implicated in cell adhesion, motility and proliferation |
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playing a crucial role for cell fusion during osteoclastogenesis after activation of the RANK/RANKL system, through its expression in lipid rafts |
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inhibiting the proliferation and tumorigenicity of colon carcinoma cells |
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regulates the actin cytoskeleton by downregulating of the WASF2, through the WNT-independent signal pathway |
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essential for sperm-egg fusion , and |
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having a function in migration and adhesion of these cells |
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involved in the migration of retinal microvascular endothelial cells |
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its mobility and partitioning are both dependent on its palmitoylation and plasma membrane cholesterol |
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has a role in the maturation of transmembrane TGFA and its stabilization at the cell surface, and in the cell-surface distribution in polarized epithelial cells |
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role in the presentation of TGFA in epithelial and carcinoma cells, whose physiology is driven by ligand-induced EGFR activation |
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might have an important role that attenuates EGFR signaling (not only associates EGFR but also a new regulator, which may affect EGF-induced signaling in cancer cells) |
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plays roles in cell proliferation and attachment as well as engraftment and can be considered as a useful marker to predict the efficacy of adipose-derived mesenchymal stem cells |
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with CD63 ssociate with a type II phosphatidylinositol 4-kinase, PI4K55, in both resting and activated platelets |
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with CD63 and CD81 are all involved in multinucleated giant cells formation, but play distinct roles |
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plays stimulus-independent roles in angiogenesis |
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appears to, at least in part, contribute to the delocalization of integrins and MMP14, disruption of which may prevent angiogenesis |
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involved in the proliferation but not survival of relatively quiescent endothelial cells |
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CD9 expression on human germinal center (GC) -B cells may reflect the status of GC-B cell activation or differentiation |
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CD9 is a marker for plasma cells precursors ( |
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normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81 |
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requirement of two spermatozoon factors, IZUMO1 and SPACA6, and two oocyte factors, CD9 and the IZUMO1R, has been proven in Sperm-egg fusion |
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IZUMO1 and C16orf92 on the sperm membrane and CD9 and IZUMO1R/FOLR4 on the oocyte membrane have been identified as fusion-required proteins |
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role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site |
