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FLASH GENE

Symbol

PRDX3

contributors: /mct - updated : 12-12-2022

HGNC name	peroxiredoxin 3
HGNC id	9354

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PPPCD punctiform and polychromatic pre-Descemet corneal dystrophy SCAR32 spinocerebellar ataxia, autosomal recessive 32
Location	10q26.11      Physical location : 120.927.215 - 120.938.345
Synonym name	antioxidant protein 1
	thioredoxin-dependent peroxide reductase precursor
	protein MER5 homolog
	epididymis secretory sperm binding protein
Synonym symbol(s)	AOP1, MER5, MGC104387, MGC24293, PRO1748, SP-22, AOP-1, prx-III
EC.number	1.11.1.15/ 1.11.1.24

DNA

TYPE	functioning gene
STRUCTURE	11.13 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D10S597 - ADD3 - D10S554 - D10S1681 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006793 7 - 1591 NP_006784 21.5 256 - 2002 12011429 NM_014098 7 - 1537 NP_054817 25.71 238 - 2002 12011429 NM_001302272 6 - 1387 NP_001289201 - 198 - 2002 12011429

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Urinary bladder       highly Visual eye retina     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor Visual ganglion cell Visual rod photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to murine Prdx3
	homolog to C.elegans R07E5.2

Homologene

FAMILY

antioxidant family of proteins synthesized in the cytoplasm and functioning in mitochondria (ahpC/TSA family)

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic
text	localized to the mitochondria (Moreira 2008)
	localized mainly to the photoreceptor inner segments, the outer and inner plexiform layers, and the ganglion cells (Moreira 2008)

basic FUNCTION	may be involved in the regulation of cellular proliferation, differentiation and antioxidant functions
	regulating erythroid differentiation (late stage of proerythrocyte differentiation)
	critical regulator of the abundance of mitochondrial H(2)O(2), which itself promotes apoptosis in cooperation with other mediators of apoptotic signaling
	may be important in protecting photoreceptor mitochondria especially in blue cones (Moreira 2008)
	PRDX3 and PRDX4, may act as new placental immune targets, and are involved in recurrent pregnancy loss
	mitochondrial peroxide reductase that regulates cellular redox state
	PRDX3 promotes hepatocellular carcinoma growth and mediates cell migration and invasiveness
	PRDX3 protected trophoblast cells against mitochondrial dysfunction and cellular senescence induced by oxidative stress
	involved in antioxidant defense and redox signaling
	PRDX3 protects against traumatic neuronal injury (TNI) insult by preserving mitochondrial function and mitochondrial biogenesis
	plays a major role in scavenging hydrogen peroxide of mitochondria
	plays an active role in the response to insulin release

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	RPS6KC1-binding protein (interacts with PRDX3 through its pseudokinase domains, and with early endosomes through its PX domain)
	interacts with TXN2 and the TXN2/PRDX3 system functions in parallel with the GSX1 system to protect mitochondria from oxidative stress (Zhang 2007)
	interaction between TNNI3K and PRDX3 (Feng 2007)

cell & other

REGULATION

induced by

hydrogen peroxide in aortic endothelial and lens epithelial cells (Moreira 2008)

ASSOCIATED DISORDERS

corresponding disease(s)

PPPCD , SCAR32

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function results in sensitivity to oxidative stress in Fanconi anemia tumoral     --over   in prostate cancer tissue tumoral     --over   in primary Uveal melanoma (UM) tissue is associated with metastasis and poor survival constitutional     --low   decreased PRDX3 by excessive bile acids in trophoblasts plays a critical role in the pathogenesis and progression of Intrahepatic cholestasis of pregnancy (ICP) constitutional     --over   in prostatic epithelial cells may promote the initiation and development of Benign prostatic hyperplasia (BPH) through autophagy inhibition and pyroptosis activation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	positive association of plasma PRDX3 and insulin suggest PRDX3 to be a potential indicator of high insulin resistance
Therapy target
	System Type Disorder Pubmed cancer digestive liver potential therapeutic target for HCC treatment neurology acquired   may have potential therapeutic value for traumatic brain injury (TBI)

ANIMAL & CELL MODELS