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FLASH GENE
Symbol PRDX3 contributors: /mct - updated : 24-01-2017
HGNC name peroxiredoxin 3
HGNC id 9354
Location 10q26.11      Physical location : 120.927.215 - 120.938.345
Synonym name
  • antioxidant protein 1
  • thioredoxin-dependent peroxide reductase precursor
  • protein MER5 homolog
  • Synonym symbol(s) AOP1, MER5, MGC104387, MGC24293, PRO1748, SP-22, AOP-1, prx-III
    EC.number 1.11.1.15
    DNA
    TYPE functioning gene
    STRUCTURE 11.13 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D10S597 - ADD3 - D10S554 - D10S1681 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1591 21.5 256 - Guo (2005)
    7 - 1537 25.71 238 - Guo (2005)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Urinarybladder   highly
    Visualeyeretina  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor
    Visualganglion cell
    Visualrod photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Prdx3
    homolog to C.elegans R07E5.2
    Homologene
    FAMILY
  • antioxidant family of proteins synthesized in the cytoplasm and functioning in mitochondria (ahpC/TSA family)
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • localized to the mitochondria (Moreira 2008)
  • localized mainly to the photoreceptor inner segments, the outer and inner plexiform layers, and the ganglion cells (Moreira 2008)
  • basic FUNCTION
  • may be involved in the regulation of cellular proliferation, differentiation and antioxidant functions
  • regulating erythroid differentiation (late stage of proerythrocyte differentiation)
  • critical regulator of the abundance of mitochondrial H(2)O(2), which itself promotes apoptosis in cooperation with other mediators of apoptotic signaling
  • may be important in protecting photoreceptor mitochondria especially in blue cones (Moreira 2008)
  • PRDX3 and PRDX4, may act as new placental immune targets, and are involved in recurrent pregnancy loss
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RPS6KC1-binding protein (interacts with PRDX3 through its pseudokinase domains, and with early endosomes through its PX domain)
  • interacts with TXN2 and the TXN2/PRDX3 system functions in parallel with the GSX1 system to protect mitochondria from oxidative stress (Zhang 2007)
  • interaction between TNNI3K and PRDX3 (Feng 2007)
  • cell & other
    REGULATION
    induced by hydrogen peroxide in aortic endothelial and lens epithelial cells (Moreira 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    results in sensitivity to oxidative stress in Fanconi anemia
    tumoral     --over  
    in prostate cancer tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS