Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PRDX3

contributors: /mct - updated : 24-01-2017

HGNC name	peroxiredoxin 3
HGNC id	9354

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q26.11      Physical location : 120.927.215 - 120.938.345
Synonym name	antioxidant protein 1
	thioredoxin-dependent peroxide reductase precursor
	protein MER5 homolog
Synonym symbol(s)	AOP1, MER5, MGC104387, MGC24293, PRO1748, SP-22, AOP-1, prx-III
EC.number	1.11.1.15

DNA

TYPE	functioning gene
STRUCTURE	11.13 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D10S597 - ADD3 - D10S554 - D10S1681 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006793 7 - 1591 NP_006784 21.5 256 - Guo (2005) NM_014098 7 - 1537 NP_054817 25.71 238 - Guo (2005)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Urinary bladder       highly Visual eye retina     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor Visual ganglion cell Visual rod photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to murine Prdx3
	homolog to C.elegans R07E5.2

Homologene

FAMILY

antioxidant family of proteins synthesized in the cytoplasm and functioning in mitochondria (ahpC/TSA family)

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
text	localized to the mitochondria (Moreira 2008)
	localized mainly to the photoreceptor inner segments, the outer and inner plexiform layers, and the ganglion cells (Moreira 2008)

basic FUNCTION	may be involved in the regulation of cellular proliferation, differentiation and antioxidant functions
	regulating erythroid differentiation (late stage of proerythrocyte differentiation)
	critical regulator of the abundance of mitochondrial H(2)O(2), which itself promotes apoptosis in cooperation with other mediators of apoptotic signaling
	may be important in protecting photoreceptor mitochondria especially in blue cones (Moreira 2008)
	PRDX3 and PRDX4, may act as new placental immune targets, and are involved in recurrent pregnancy loss

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	RPS6KC1-binding protein (interacts with PRDX3 through its pseudokinase domains, and with early endosomes through its PX domain)
	interacts with TXN2 and the TXN2/PRDX3 system functions in parallel with the GSX1 system to protect mitochondria from oxidative stress (Zhang 2007)
	interaction between TNNI3K and PRDX3 (Feng 2007)

cell & other

REGULATION

induced by

hydrogen peroxide in aortic endothelial and lens epithelial cells (Moreira 2008)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function results in sensitivity to oxidative stress in Fanconi anemia tumoral     --over   in prostate cancer tissue

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS