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FLASH GENE

Symbol

ADD3

contributors: - updated : 31-03-2006

HGNC name	adducin 3 (gamma)
HGNC id	245

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q24.2-q24.3      Physical location : 111.765.725 - 111.895.320

DNA

TYPE	functioning gene
STRUCTURE	33.00 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ADD3 V1 - - 4437 - 706 - Gilligan ADD3 V2 - - 4107 - 674 - Gilligan

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       moderately Urinary kidney renal medulla     highly   kidney

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal globular protease resistent domain
	a potential protein kinase C phosphorylation site
	a calmodulin binding site
	a C terminus homolog to MARCKS proteins, alternatively spliced

mono polymer

homomer , heptamer

HOMOLOGY

Homologene

FAMILY

aldolase class II family, adducin subfamily

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus

basic FUNCTION

membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma

INTERACTION

DNA

RNA

small molecule

protein

calmodulin binding

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS