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FLASH GENE

Symbol

MSRB2

contributors: mct - updated : 04-02-2011

HGNC name	methionine sulfoxide reductase B2
HGNC id	17061

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10p12.2      Physical location : 23.384.426 - 23.410.941
Synonym name	pilin-like transcription factor
	methionine-R-sulfoxide reductase B2, mitochondrial
Synonym symbol(s)	CBS1, CGI-131, CBS-1, MSRB, PILB, MGC26104
EC.number	1.8.4.-

DNA

TYPE	functioning gene
STRUCTURE	26.52 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012228 5 - 1811 NP_036360 - 182 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly   vessel aorta     highly Nervous brain       moderately Respiratory lung       highly Skin/Tegument skin         Homo sapiens Urinary kidney       highly Visual eye lens       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument melanocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal region exhibiting significant identity in a stretch of 20 AA with glycine-rich proteins
	a C terminal region highly homolog to the C terminus of the peptide-methionine sulfoxide reductase, a repair enzyme of Helicobacter pylori and Streptococcus pneumoniae

HOMOLOGY

interspecies

homolog to E.coli pilB and MsrA

Homologene

FAMILY

MSRB MET sulfoxide reductase family

CATEGORY

enzyme , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
text	localized in the mitochondria

basic FUNCTION	specifically reducing methionine-R-sulfoxide
	with SEPX1, and MSRB3, required for lens cell viability, and their silencing in lens cells results in increased oxidative-stress-induced cell death
	important as antioxidant/repair systems for neutrophils, cells with enormous capacity for the generation of reactive oxidants and hence, susceptible to oxidative damage
	repair enzymes that protect proteins from oxidative stress by catalyzing stereospecific reduction of oxidized methionine residues

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction with selenocompounds which can serve as oxidoreductants

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS