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Symbol MSRB2 contributors: mct - updated : 04-02-2011
HGNC name methionine sulfoxide reductase B2
HGNC id 17061
Location 10p12.2      Physical location : 23.384.426 - 23.410.941
Synonym name
  • pilin-like transcription factor
  • methionine-R-sulfoxide reductase B2, mitochondrial
  • Synonym symbol(s) CBS1, CGI-131, CBS-1, MSRB, PILB, MGC26104
    EC.number 1.8.4.-
    DNA
    TYPE functioning gene
    STRUCTURE 26.52 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1811 - 182 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vesselaorta  highly
    Nervousbrain   moderately
    Respiratorylung   highly
    Skin/Tegumentskin     Homo sapiens
    Urinarykidney   highly
    Visualeyelens    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentmelanocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal region exhibiting significant identity in a stretch of 20 AA with glycine-rich proteins
  • a C terminal region highly homolog to the C terminus of the peptide-methionine sulfoxide reductase, a repair enzyme of Helicobacter pylori and Streptococcus pneumoniae
  • HOMOLOGY
    interspecies homolog to E.coli pilB and MsrA
    Homologene
    FAMILY
  • MSRB MET sulfoxide reductase family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text localized in the mitochondria
    basic FUNCTION
  • specifically reducing methionine-R-sulfoxide
  • with SEPX1, and MSRB3, required for lens cell viability, and their silencing in lens cells results in increased oxidative-stress-induced cell death
  • important as antioxidant/repair systems for neutrophils, cells with enormous capacity for the generation of reactive oxidants and hence, susceptible to oxidative damage
  • repair enzymes that protect proteins from oxidative stress by catalyzing stereospecific reduction of oxidized methionine residues
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interaction with selenocompounds which can serve as oxidoreductants
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS