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FLASH GENE
Symbol ITGB1 contributors: mct - updated : 26-10-2017
HGNC name integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
HGNC id 6153
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 20 amino acids signal peptide (2,2 kDa)
  • a globular domain
  • a stalk region with several EGF-like repeats each with eight cysteine residues
  • a single transmembrane (TM) and a short cytoplasmic tail
  • a von Willebrand factor (VWF) type A domain
    • mono polymer heteromer , dimer
    isoforms Precursor a 778 amino acids mature peptide (86,2 kDa)
    HOMOLOGY
    interspecies homolog to rattus Itgb1 (90.60 pc)
    homolog to murine Itgb1 (91.23 pc)
    intraspecies homolog to ITGB2
    Homologene
    FAMILY
  • integrin beta chain family
    • CATEGORY adhesion , antigen , signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text coexpressed in prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B)
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • inhibitor of cell proliferation
  • involved in migration and survival in primary oligodendrocytes
  • dispensable for the initiation of ERBB2 tumor induction, it plays a critical role in metastatic phase of tumor progression
  • essential for normal wound healing, where it acts, at least in part, through a TGFBeta-dependent mechanism
  • critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory
  • required both for fibroblast chemotaxis towards platelet-derived growth factor (PDGF) and growth factor-induced dorsal ruffling
  • SEMA7A on keratinocytes and ITGB1 on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, such as psoriasis or wound
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    text promoting a cell migratory phenotype in association with PRKCA
    PATHWAY
    metabolism
    signaling
  • ITGB1-WNT7A-DCN pathway promotes proliferation and differentiation of neuroepithelial cells, and identify DCN as a novel neurogenic factor in the central nervous system
    • a component
  • dimerizing with ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV (see symbols)
  • complexing with PRKCA
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targeting ERM proteins, MSN, RDX, EZR in association with PRKCA
  • YWHAB
  • associate with insulin-like growth factor type 1 receptor (IGF-IR) and regulate IGF-stimulated prostate cancer cell proliferation
  • interacting with RET (can activate ITGB1, and that RET-induced cell adhesion and migration require ITGB1)
  • ITGB1 is a transcriptional target of HOXD1 in endothelial cells
  • SERPINB5 physically associates with both PLAUR and ITGB1, thus producing a complex that regulates both cell motility and adhesion
  • TLN1 binds to ITGB1 cytoplasmic tails and regulates integrin activation
  • PML regulates endothelial cell migration, in part, by modulating expression of downstream genes, such as ITGB1
  • NELL1 binds to extracellular ITGB1 and induces cell focal adhesion
  • SOX10 and ITGB1 interaction in enteric neural crest cell migration
  • ARAP2 and ACAP1 had opposing effects on apparent ITGB1 internalization
  • RAB23 promotes squamous cell carcinoma cells migration and invasion by regulating ITGB1/TIAM1/RAC1 pathway
  • MARVELD1 regulated neuronal migration by mediating the formation of glial fibres and ITGB1/PTK2 signalling pathway
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
  • dysregulation of protein expression
  • coexpressed in human prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B)
    • Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS