Citations for
1ITGB1, RAB23, RAC1, TIAM1
Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin β1/Rac1 pathway.
Jian Q, Miao Y, Tang L, Huang M, Yang Y, Ba W, Liu Y, Chi S, Li C.
Oncotarget 7(5):5342-52. doi: 10.18632/oncotarget.6701. 2016
2DCN, ITGB1, WNT7A
Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
Long K, Moss L, Laursen L, Boulter L, ffrench-Constant C.
Nat Commun 7:10354. doi: 10.1038/ncomms10354. 2016
3ACAP1, ARAP2, ITGB1
The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic.
Chen PW, Luo R, Jian X, Randazzo PA.
J Biol Chem 289(44):30237-48. doi: 10.1074/jbc.M114.596155. Epub 2014 Sep 15. 2014
4ITGB1, SOX10
Sox10 and Itgb1 interaction in enteric neural crest cell migration.
Watanabe Y, Broders-Bondon F, Baral V, Paul-Gilloteaux P, Pingault V, Dufour S, Bondurand N.
Dev Biol 379(1):92-106. doi: 10.1016/j.ydbio.2013.04.013. Epub 2013 Apr 19. 2013
5ITGB1
Lck tyrosine kinase mediates β1-integrin signalling to regulate Schwann cell migration and myelination.
Ness JK, Snyder KM, Tapinos N.
Nat Commun 4:1912. doi: 10.1038/ncomms2928. 2013
6ITGB1, PML
Promyelocytic leukemia protein (PML) regulates endothelial cell network formation and migration in response to tumor necrosis factor α (TNFα) and interferon α (IFNα).
Cheng X, Liu Y, Chu H, Kao HY.
J Biol Chem 287(28):23356-67. doi: 10.1074/jbc.M112.340505. Epub 2012 May 15. 2012
7ITGB1, NELL1
NELL-1 promotes cell adhesion and differentiation via Integrinβ1.
Shen J, James AW, Chung J, Lee K, Zhang JB, Ho S, Lee KS, Kim TM, Niimi T, Kuroda S, Ting K, Soo C.
J Cell Biochem 113(12):3620-8. doi: 10.1002/jcb.24253. 2012
8HOXD1, ITGB1
Homeobox D1 regulates angiogenic functions of endothelial cells via integrin β1 expression.
Park H, Choi HJ, Kim J, Kim M, Rho SS, Hwang D, Kim YM, Kwon YG.
Biochem Biophys Res Commun 408(1):186-92. Epub 2011 Apr 9. 2011
9ITGB1
β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability.
King SJ, Worth DC, Scales TM, Monypenny J, Jones GE, Parsons M.
EMBO J 30(9):1705-18. Epub 2011 Mar 22. 2011
10ITGB1
β1 integrin is critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory.
DeNucci CC, Shimizu Y.
J Immunol 186(7):4019-26. Epub 2011 Feb 25. 2011
11ITGB1, PLAUR, SERPINB5
Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion.
Endsley MP, Hu Y, Deng Y, He X, Warejcka DJ, Twining SS, Gonias SL, Zhang M.
J Biol Chem 286(28):24599-607. Epub 2011 May 23. 2011
12ITGB1, TLN1
Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.
Liu J, He X, Qi Y, Tian X, Monkley SJ, Critchley DR, Corbett SA, Lowry SF, Graham AM, Li S.
Mol Cell Biol 31(16):3366-77. Epub 2011 Jun 13. 2011
13ITGB1, SEMA7A
Semaphorin 7A on keratinocytes induces interleukin-8 production by monocytes.
Kamata M, Tada Y, Uratsuji H, Kawashima T, Asano Y, Sugaya M, Kadono T, Tamaki K, Sato S.
J Dermatol Sci 62(3):176-82. doi: 10.1016/j.jdermsci.2011.02.004. Epub 2011 Feb 26. 2011
14ITGB1, RET
RET-Mediated Cell Adhesion and Migration Require Multiple Integrin Subunits.
Cockburn JG, Richardson DS, Gujral TS, Mulligan LM.
J Clin Endocrinol Metab Clin Endocrinol Metab. 2010 Aug 11. [Epub ahead of print]PMID: 20702524 2010
15ITGB1
Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo.
Liu S, Xu SW, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A.
J Cell Sci 123(Pt 21):3674-82. Epub 2010 Oct 12. 2010
16ITGB1
beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression.
Huck L, Pontier SM, Zuo DM, Muller WJ.
Proc Natl Acad Sci U S A 107(35):15559-64. Epub 2010 Aug 16. 2010
17ITGB1
Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1.
Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR.
J Cell Physiol 224(1):210-7. 2010
18ITGB1, KIF2A
Targeting of integrin beta1 and kinesin 2alpha by microRNA 183.
Li G, Luna C, Qiu J, Epstein DL, Gonzalez P.
J Biol Chem 285(8):5461-71. doi: 10.1074/jbc.M109.037127. Epub 2009 Nov 24. 2010
19ITGB1, PLAUR, SPINK7
ECRG2 regulates cell migration/invasion through urokinase-type plasmin activator receptor (uPAR)/beta1 integrin pathway.
Cheng X, Shen Z, Yin L, Lu SH, Cui Y.
J Biol Chem 284(45):30897-906. Epub 2009 Aug 28. 2009
20ITGA9, ITGB1
The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.
Schreiber TD, Steinl C, Essl M, Abele H, Geiger K, Müller CA, Aicher WK, Klein G.
Haematologica 94(11):1493-501. Epub 2009 Jul 16. 2009
21ITGA9, ITGB1
Polymeric osteopontin employs integrin alpha9beta1 as a receptor and attracts neutrophils by presenting a de novo binding site.
Nishimichi N, Higashikawa F, Kinoh HH, Tateishi Y, Matsuda H, Yokosaki Y.
J Biol Chem 284(22):14769-76. Epub 2009 Apr 3. 2009
22GPNMB, ITGB1, ITGB3
Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity.
Sheng MH, Wergedal JE, Mohan S, Lau KH.
FEBS Lett 582(10):1451-8. Epub 2008 Mar 31. 2008
23ITGA9, ITGB1
Integrin alpha9 beta1 is a receptor for nerve growth factor and other neurotrophins.
Staniszewska I, Sariyer IK, Lecht S, Brown MC, Walsh EM, Tuszynski GP, Safak M, Lazarovici P, Marcinkiewicz C.
J Cell Sci 121(Pt 4):504-13. Epub 2008 Jan 29. 2008
24ITGA1, ITGA2, ITGB1
Determination of the ligand-binding specificities of the alpha2beta1 and alpha1beta1 integrins in a novel 3-dimensional in vitro model of pancreatic cancer.
Grzesiak JJ, Bouvet M.
Pancreas 34(2):220-8. 2007
25ITGA1,ITGB1,SEMA7A
Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin.
Suzuki K, Okuno T, Yamamoto M, Pasterkamp RJ, Takegahara N, Takamatsu H, Kitao T, Takagi J, Rennert PD, Kolodkin AL, Kumanogoh A, Kikutani H.
Nature 446(7136):680-4. Epub 2007 Mar 21. 2007
26SLC3A2, ITGB1
CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling.
Prager GW, Feral CC, Kim C, Han J, Ginsberg MH.
J Biol Chem 282(33):24477-84. Epub 2007 Jun 27. 2007
27CDH13, ITGB1
T-cadherin enhances cell-matrix adhesiveness by regulating beta1 integrin trafficking in cutaneous squamous carcinoma cells.
Mukoyama Y, Utani A, Matsui S, Zhou S, Miyachi Y, Matsuyoshi N.
Genes Cells 12(6):787-96. 2007
28ITGA9, ITGB1, THBS1
Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis.
Staniszewska I, Zaveri S, Del Valle L, Oliva I, Rothman VL, Croul SE, Roberts DD, Mosher DF, Tuszynski GP, Marcinkiewicz C.
Circ Res 100(9):1308-16. Epub 2007 Apr 5. 2007
29ITGA1, ITGA2, ITGB1
Expression of Collagen-Binding Integrin Receptors in the Mammalian Sclera and Their Regulation during the Development of Myopia.
McBrien NA, Metlapally R, Jobling AI, Gentle A.
Invest Ophthalmol Vis Sci 47(11):4674-82. 2006
30LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMC1, LAMC2, LAMC3, ITGA3, ITGA6, ITGB1, ITGB4
Retinal pigment epithelial cells synthesize laminins, including laminin 5, and adhere to them through alpha3- and alpha6-containing integrins.
Aisenbrey S, Zhang M, Bacher D, Yee J, Brunken WJ, Hunter DD.
Invest Ophthalmol Vis Sci 47(12):5537-44. 2006
31ITGA3, ITGB1, ITGB3, ITGAV
Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3.
Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG, Zent R.
J Biol Chem 281(30):20932-9. Epub 2006 May 26. 2006
32ITGA3, ITGB1, PLAUR
Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways.
Ghosh S, Johnson JJ, Sen R, Mukhopadhyay S, Liu Y, Zhang F, Wei Y, Chapman HA, Stack MS.
J Biol Chem 281(19):13021-9. Epub 2006 Mar 1. 2006
33ITGA1, ITGB1, ITGA2, COL3A1
A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1.
Kim JK, Xu Y, Xu X, Keene DR, Gurusiddappa S, Liang X, Wary KK, Hook M.
J Biol Chem 280(37):32512-20. Epub 2005 Jul 21. 2005
34ADAM12,ITGB1,ITGB3
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
Thodeti CK, Frohlich C, Nielsen CK, Takada Y, Fassler R, Albrechtsen R, Wewer UM.
FEBS Lett 579(25):5589-95. Epub 2005 Sep 28. 2005
35SLC3A2, ITGB1
CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation.
Henderson NC, Collis EA, Mackinnon AC, Simpson KJ, Haslett C, Zent R, Ginsberg M, Sethi T.
J Biol Chem 279(52):54731-41. Epub 2004 Oct 12. 2004
36ITGB1
Splice variants of human beta 1 integrins: origin, biosynthesis and functions.
Armulik A.
Front Biosci 7:d219-27. Review. 2002
37ITGB1, MSN, PRKCA, RDX, EZR
Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility.
Ng T, Parsons M, Hughes WE, Monypenny J, Zicha D, Gautreau A, Arpin M, Gschmeissner S, Verveer PJ, Bastiaens PI, Parker PJ.
EMBO J 20(11):2723-2741. 2001
38ITGB1, YWHAB
Identification of a novel interaction between integrin beta1 and 14-3-3beta.
Han DC, Rodriguez LG, Guan JL.
Oncogene 20(3):346-57. 2001
39KRIT1, ITGB1BP1, ITGB1, CCM1
Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation.
Zhang J, Clatterbuck RE, Rigamonti D, Chang DD, Dietz HC.
Hum Mol Genet 10(25):2953-60. 2001
40CDKN1B, ITGB1
p27(kip1) acts as a downstream effector of and is coexpressed with the beta1C integrin in prostatic adenocarcinoma.
Fornaro M, Tallini G, Zheng DQ, Flanagan WM, Manzotti M, Languino LR.
J Clin Invest 103(3):321-9. 1999
41ITGB1
Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro.
Zhu AJ, Haase I, Watt FM.
Proc Natl Acad Sci U S A 96(12):6728-33. 1999
42ITGB1
Mapping regions of the beta1 integrin cytoplasmic domain involved in migration and survival in primary oligodendrocyte precursors using cell-permeable homeopeptides.
Buttery PC, Mallawaarachchi CM, Milner R, Doherty P, ffrench-Constant C.
Biochem Biophys Res Commun 259(1):121-7. 1999
43ITGB4, ITGB1
Expression of beta1 and beta4 integrins in normal arachnoid membrane and meningiomas.
Beschet I, Brunon J, Scoazec JY, Mosnier JF.
Cancer 86(12):2649-58. 1999
44ITGB1
The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.
Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R.
J Biol Chem 270(39):23196-202. 1995
45ITGB1, RET
Characterization of the FNRB locus with YAC clones and identification of new highly informative flanking markers for predictive testing in multiple endocrine neoplasia type 2 (MEN2).
Lairmore TC, et al.
Am J Hum Genet 49S : 348. 1991
46FNRBL, ITGB1
Fibronectin receptor beta subunit locus : DNA polymorphism and linkage mapping studies based on non-CEPH families.
Wu J, et al.
(HGM10) Cytogenet Cell Genet 51 : 1110-1111. 1989
47ITGB1
The locus for multiple endocrine neoplasia 2A (MEN2A) is linked to two 10p and two 10q markers with an SRO of 10p11.2 to 10q11.2.
Myers S, et al.
(HGM10) Cytogenet Cell Genet 51 : 1050. 1989
48ITGB1
Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2.
Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN.
Ann Hum Genet 53(Pt 1):15-22. 1989
49ITGB1
The beta subunit locus of the human fibronectin receptor: DNA restriction fragment length polymorphism and linkage mapping studies.
Wu JS, Giuffra LA, Goodfellow PJ, Myers S, Carson NL, Anderson L, Hoyle LS, Simpson NE, Kidd KK.
Hum Genet 83(4):383-90. 1989
50ITGA2B, ITGB3, ITGAV, ITGA5, ITGB1
Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa.
Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al.
J Clin Invest 81(6):1993-8. 1988
51ITGB1
Mapping of human fibronectin receptor beta subunit gene to chromosome 10.
Zhang Y, Saison M, Spaepen M, De Strooper B, Van Leuven F, David G, Van den Berghe H, Cassiman JJ.
Somat Cell Mol Genet 14(1):99-104. 1988
52ITGB1
Genetic and biochemical characterization of human lymphocyte cell surface antigens. The A-1A5 and A-3A4 determinants.
Peters PM, Kamarck ME, Hemler ME, Strominger JL, Ruddle FH.
J Exp Med 159(5):1441-54. 1984