| 1 | ITGB1, MARVELD1, PTK2
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| MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development
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| Liu W, Han F, Qu S, Yao Y, Zhao J, Akhtar ML, Ci Y, Zhang H, Li H, Zhao Y, Yue L, Zhang Y, Wang C, Li Y.
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| Cell Death Dis. Sep 24;9(10):999. doi: 10.1038/s41419-018-1027-6. 2018
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| 2 | ITGB1, RAB23, RAC1, TIAM1
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| Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin β1/Rac1 pathway.
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| Jian Q, Miao Y, Tang L, Huang M, Yang Y, Ba W, Liu Y, Chi S, Li C.
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| Oncotarget 7(5):5342-52. doi: 10.18632/oncotarget.6701.
2016
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| 3 | DCN, ITGB1, WNT7A
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| Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
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| Long K, Moss L, Laursen L, Boulter L, ffrench-Constant C.
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| Nat Commun 7:10354. doi: 10.1038/ncomms10354.
2016
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| 4 | ACAP1, ARAP2, ITGB1
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| The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic.
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| Chen PW, Luo R, Jian X, Randazzo PA.
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| J Biol Chem 289(44):30237-48. doi: 10.1074/jbc.M114.596155. Epub 2014 Sep 15.
2014
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| 5 | ITGB1, SOX10
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| Sox10 and Itgb1 interaction in enteric neural crest cell migration.
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| Watanabe Y, Broders-Bondon F, Baral V, Paul-Gilloteaux P, Pingault V, Dufour S, Bondurand N.
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| Dev Biol 379(1):92-106. doi: 10.1016/j.ydbio.2013.04.013. Epub 2013 Apr 19.
2013
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| 6 | ITGB1
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| Lck tyrosine kinase mediates β1-integrin signalling to regulate Schwann cell migration and myelination.
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| Ness JK, Snyder KM, Tapinos N.
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| Nat Commun 4:1912. doi: 10.1038/ncomms2928.
2013
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| 7 | ITGB1, PML
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| Promyelocytic leukemia protein (PML) regulates endothelial cell network formation and migration in response to tumor necrosis factor α (TNFα) and interferon α (IFNα).
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| Cheng X, Liu Y, Chu H, Kao HY.
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| J Biol Chem 287(28):23356-67. doi: 10.1074/jbc.M112.340505. Epub 2012 May 15.
2012
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| 8 | ITGB1, NELL1
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| NELL-1 promotes cell adhesion and differentiation via Integrinβ1.
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| Shen J, James AW, Chung J, Lee K, Zhang JB, Ho S, Lee KS, Kim TM, Niimi T, Kuroda S, Ting K, Soo C.
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| J Cell Biochem 113(12):3620-8. doi: 10.1002/jcb.24253.
2012
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| 9 | HOXD1, ITGB1
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| Homeobox D1 regulates angiogenic functions of endothelial cells via integrin β1 expression.
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| Park H, Choi HJ, Kim J, Kim M, Rho SS, Hwang D, Kim YM, Kwon YG.
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| Biochem Biophys Res Commun 408(1):186-92. Epub 2011 Apr 9.
2011
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| 10 | ITGB1
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| β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability.
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| King SJ, Worth DC, Scales TM, Monypenny J, Jones GE, Parsons M.
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| EMBO J 30(9):1705-18. Epub 2011 Mar 22.
2011
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| 11 | ITGB1
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| β1 integrin is critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory.
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| DeNucci CC, Shimizu Y.
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| J Immunol 186(7):4019-26. Epub 2011 Feb 25.
2011
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| 12 | ITGB1, PLAUR, SERPINB5
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| Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion.
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| Endsley MP, Hu Y, Deng Y, He X, Warejcka DJ, Twining SS, Gonias SL, Zhang M.
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| J Biol Chem 286(28):24599-607. Epub 2011 May 23.
2011
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| 13 | ITGB1, TLN1
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| Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.
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| Liu J, He X, Qi Y, Tian X, Monkley SJ, Critchley DR, Corbett SA, Lowry SF, Graham AM, Li S.
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| Mol Cell Biol 31(16):3366-77. Epub 2011 Jun 13.
2011
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| 14 | ITGB1, SEMA7A
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| Semaphorin 7A on keratinocytes induces interleukin-8 production by monocytes.
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| Kamata M, Tada Y, Uratsuji H, Kawashima T, Asano Y, Sugaya M, Kadono T, Tamaki K, Sato S.
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| J Dermatol Sci 62(3):176-82. doi: 10.1016/j.jdermsci.2011.02.004. Epub 2011 Feb 26.
2011
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| 15 | ITGB1, RET
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| RET-Mediated Cell Adhesion and Migration Require Multiple Integrin Subunits.
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| Cockburn JG, Richardson DS, Gujral TS, Mulligan LM.
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| J Clin Endocrinol Metab Clin Endocrinol Metab. 2010 Aug 11. [Epub ahead of print]PMID: 20702524 2010
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| 16 | ITGB1
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| Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo.
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| Liu S, Xu SW, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A.
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| J Cell Sci 123(Pt 21):3674-82. Epub 2010 Oct 12.
2010
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| 17 | ITGB1
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| beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression.
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| Huck L, Pontier SM, Zuo DM, Muller WJ.
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| Proc Natl Acad Sci U S A 107(35):15559-64. Epub 2010 Aug 16.
2010
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| 18 | ITGB1
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| Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1.
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| Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR.
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| J Cell Physiol 224(1):210-7.
2010
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| 19 | ITGB1, KIF2A
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| Targeting of integrin beta1 and kinesin 2alpha by microRNA 183.
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| Li G, Luna C, Qiu J, Epstein DL, Gonzalez P.
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| J Biol Chem 285(8):5461-71. doi: 10.1074/jbc.M109.037127. Epub 2009 Nov 24.
2010
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| 20 | ITGB1, PLAUR, SPINK7
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| ECRG2 regulates cell migration/invasion through urokinase-type plasmin activator receptor (uPAR)/beta1 integrin pathway.
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| Cheng X, Shen Z, Yin L, Lu SH, Cui Y.
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| J Biol Chem 284(45):30897-906. Epub 2009 Aug 28.
2009
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| 21 | ITGA9, ITGB1
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| The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.
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| Schreiber TD, Steinl C, Essl M, Abele H, Geiger K, Müller CA, Aicher WK, Klein G.
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| Haematologica 94(11):1493-501. Epub 2009 Jul 16.
2009
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| 22 | ITGA9, ITGB1
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| Polymeric osteopontin employs integrin alpha9beta1 as a receptor and attracts neutrophils by presenting a de novo binding site.
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| Nishimichi N, Higashikawa F, Kinoh HH, Tateishi Y, Matsuda H, Yokosaki Y.
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| J Biol Chem 284(22):14769-76. Epub 2009 Apr 3. 2009
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| 23 | GPNMB, ITGB1, ITGB3
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| Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity.
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| Sheng MH, Wergedal JE, Mohan S, Lau KH.
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| FEBS Lett 582(10):1451-8. Epub 2008 Mar 31. 2008
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| 24 | ITGA9, ITGB1
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| Integrin alpha9 beta1 is a receptor for nerve growth factor and other neurotrophins.
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| Staniszewska I, Sariyer IK, Lecht S, Brown MC, Walsh EM, Tuszynski GP, Safak M, Lazarovici P, Marcinkiewicz C.
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| J Cell Sci 121(Pt 4):504-13. Epub 2008 Jan 29.
2008
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| 25 | ITGA1, ITGA2, ITGB1
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| Determination of the ligand-binding specificities of the alpha2beta1 and alpha1beta1 integrins in a novel 3-dimensional in vitro model of pancreatic cancer.
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| Grzesiak JJ, Bouvet M.
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| Pancreas 34(2):220-8. 2007
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| 26 | ITGA1,ITGB1,SEMA7A
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| Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin.
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| Suzuki K, Okuno T, Yamamoto M, Pasterkamp RJ, Takegahara N, Takamatsu H, Kitao T, Takagi J, Rennert PD, Kolodkin AL, Kumanogoh A, Kikutani H.
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| Nature 446(7136):680-4. Epub 2007 Mar 21. 2007
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| 27 | SLC3A2, ITGB1
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| CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling.
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| Prager GW, Feral CC, Kim C, Han J, Ginsberg MH.
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| J Biol Chem 282(33):24477-84. Epub 2007 Jun 27. 2007
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| 28 | CDH13, ITGB1
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| T-cadherin enhances cell-matrix adhesiveness by regulating beta1 integrin trafficking in cutaneous squamous carcinoma cells.
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| Mukoyama Y, Utani A, Matsui S, Zhou S, Miyachi Y, Matsuyoshi N.
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| Genes Cells 12(6):787-96.
2007
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| 29 | ITGA9, ITGB1, THBS1
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| Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis.
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| Staniszewska I, Zaveri S, Del Valle L, Oliva I, Rothman VL, Croul SE, Roberts DD, Mosher DF, Tuszynski GP, Marcinkiewicz C.
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| Circ Res 100(9):1308-16. Epub 2007 Apr 5.
2007
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| 30 | ITGA1, ITGA2, ITGB1
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| Expression of Collagen-Binding Integrin Receptors in the Mammalian Sclera and Their Regulation during the Development of Myopia.
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| McBrien NA, Metlapally R, Jobling AI, Gentle A.
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| Invest Ophthalmol Vis Sci 47(11):4674-82. 2006
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| 31 | LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMC1, LAMC2, LAMC3, ITGA3, ITGA6, ITGB1, ITGB4
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| Retinal pigment epithelial cells synthesize laminins, including laminin 5, and adhere to them through alpha3- and alpha6-containing integrins.
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| Aisenbrey S, Zhang M, Bacher D, Yee J, Brunken WJ, Hunter DD.
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| Invest Ophthalmol Vis Sci 47(12):5537-44. 2006
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| 32 | ITGA3, ITGB1, ITGB3, ITGAV
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| Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3.
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| Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG, Zent R.
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| J Biol Chem 281(30):20932-9. Epub 2006 May 26. 2006
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| 33 | ITGA3, ITGB1, PLAUR
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| Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways.
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| Ghosh S, Johnson JJ, Sen R, Mukhopadhyay S, Liu Y, Zhang F, Wei Y, Chapman HA, Stack MS.
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| J Biol Chem 281(19):13021-9. Epub 2006 Mar 1. 2006
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| 34 | ITGA1, ITGB1, ITGA2, COL3A1
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| A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1.
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| Kim JK, Xu Y, Xu X, Keene DR, Gurusiddappa S, Liang X, Wary KK, Hook M.
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| J Biol Chem 280(37):32512-20. Epub 2005 Jul 21. 2005
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| 35 | ADAM12,ITGB1,ITGB3
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| ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
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| Thodeti CK, Frohlich C, Nielsen CK, Takada Y, Fassler R, Albrechtsen R, Wewer UM.
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| FEBS Lett 579(25):5589-95. Epub 2005 Sep 28. 2005
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| 36 | SLC3A2, ITGB1
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| CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation.
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| Henderson NC, Collis EA, Mackinnon AC, Simpson KJ, Haslett C, Zent R, Ginsberg M, Sethi T.
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| J Biol Chem 279(52):54731-41. Epub 2004 Oct 12. 2004
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| 37 | ITGB1
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| Splice variants of human beta 1 integrins: origin, biosynthesis and functions.
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| Armulik A.
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| Front Biosci 7:d219-27. Review.
2002
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| 38 | ITGB1, MSN, PRKCA, RDX, EZR
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| Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility.
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| Ng T, Parsons M, Hughes WE, Monypenny J, Zicha D, Gautreau A, Arpin M, Gschmeissner S, Verveer PJ, Bastiaens PI, Parker PJ.
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| EMBO J 20(11):2723-2741. 2001
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| 39 | ITGB1, YWHAB
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| Identification of a novel interaction between integrin beta1 and 14-3-3beta.
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| Han DC, Rodriguez LG, Guan JL.
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| Oncogene 20(3):346-57. 2001
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| 40 | KRIT1, ITGB1BP1, ITGB1, CCM1
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| Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation.
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| Zhang J, Clatterbuck RE, Rigamonti D, Chang DD, Dietz HC.
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| Hum Mol Genet 10(25):2953-60. 2001
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| 41 | CDKN1B, ITGB1
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| p27(kip1) acts as a downstream effector of and is coexpressed with the beta1C integrin in prostatic adenocarcinoma.
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| Fornaro M, Tallini G, Zheng DQ, Flanagan WM, Manzotti M, Languino LR.
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| J Clin Invest 103(3):321-9. 1999
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| 42 | ITGB1
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| Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro.
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| Zhu AJ, Haase I, Watt FM.
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| Proc Natl Acad Sci U S A 96(12):6728-33. 1999
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| 43 | ITGB1
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| Mapping regions of the beta1 integrin cytoplasmic domain involved in migration and survival in primary oligodendrocyte precursors using cell-permeable homeopeptides.
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| Buttery PC, Mallawaarachchi CM, Milner R, Doherty P, ffrench-Constant C.
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| Biochem Biophys Res Commun 259(1):121-7. 1999
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| 44 | ITGB4, ITGB1
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| Expression of beta1 and beta4 integrins in normal arachnoid membrane and meningiomas.
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| Beschet I, Brunon J, Scoazec JY, Mosnier JF.
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| Cancer 86(12):2649-58. 1999
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| 45 | ITGB1
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| The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.
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| Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R.
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| J Biol Chem 270(39):23196-202. 1995
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| 46 | ITGB1, RET
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| Characterization of the FNRB locus with YAC clones and identification of new highly informative flanking markers for predictive testing in multiple endocrine neoplasia type 2 (MEN2).
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| Lairmore TC, et al.
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| Am J Hum Genet 49S : 348. 1991
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| 47 | FNRBL, ITGB1
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| Fibronectin receptor beta subunit locus : DNA polymorphism and linkage mapping studies based on non-CEPH families.
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| Wu J, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 1110-1111. 1989
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| 48 | ITGB1
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| The locus for multiple endocrine neoplasia 2A (MEN2A) is linked to two 10p and two 10q markers with an SRO of 10p11.2 to 10q11.2.
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| Myers S, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 1050. 1989
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| 49 | ITGB1
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| Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2.
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| Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN.
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| Ann Hum Genet 53(Pt 1):15-22. 1989
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| 50 | ITGB1
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| The beta subunit locus of the human fibronectin receptor: DNA restriction fragment length polymorphism and linkage mapping studies.
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| Wu JS, Giuffra LA, Goodfellow PJ, Myers S, Carson NL, Anderson L, Hoyle LS, Simpson NE, Kidd KK.
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| Hum Genet 83(4):383-90. 1989
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| 51 | ITGA2B, ITGB3, ITGAV, ITGA5, ITGB1
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| Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa.
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| Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al.
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| J Clin Invest 81(6):1993-8. 1988
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| 52 | ITGB1
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| Mapping of human fibronectin receptor beta subunit gene to chromosome 10.
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| Zhang Y, Saison M, Spaepen M, De Strooper B, Van Leuven F, David G, Van den Berghe H, Cassiman JJ.
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| Somat Cell Mol Genet 14(1):99-104. 1988
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| 53 | ITGB1
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| Genetic and biochemical characterization of human lymphocyte cell surface antigens. The A-1A5 and A-3A4 determinants.
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| Peters PM, Kamarck ME, Hemler ME, Strominger JL, Ruddle FH.
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| J Exp Med 159(5):1441-54. 1984
|