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FLASH GENE

Symbol

ITGB1

contributors: mct - updated : 26-10-2017

HGNC name	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
HGNC id	6153

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Digestive mouth       moderately Endocrine parathyroid       moderately Hearing/Equilibrium ear inner cochlea   moderately Reproductive female system uterus     moderately   male system prostate     lowly Respiratory respiratory tract trachea     highly Visual eye       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective       highly Connective bone     moderately Epithelial barrier lining     lowly Muscular striatum skeletal   highly

cells

System Cell Pubmed Species Stage Rna symbol Reproductive epithelial cell

cell lineage	epidermal cells of the basal layer (stem, transit-amplifying, commited basal cells)
cell lines	Schwannomas
fluid/secretion

at STAGE

physiological period

embryo

Text	umbilical cord and embryonic tissue at an higly level

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 20 amino acids signal peptide (2,2 kDa)
	a globular domain
	a stalk region with several EGF-like repeats each with eight cysteine residues
	a single transmembrane (TM) and a short cytoplasmic tail
	a von Willebrand factor (VWF) type A domain

mono polymer

heteromer , dimer

isoforms

Precursor

a 778 amino acids mature peptide (86,2 kDa)

HOMOLOGY

interspecies	homolog to rattus Itgb1 (90.60 pc)
	homolog to murine Itgb1 (91.23 pc)

intraspecies

homolog to ITGB2

Homologene

FAMILY

integrin beta chain family

CATEGORY

adhesion , antigen , signaling , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	coexpressed in prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B)

basic FUNCTION	cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
	inhibitor of cell proliferation
	involved in migration and survival in primary oligodendrocytes
	dispensable for the initiation of ERBB2 tumor induction, it plays a critical role in metastatic phase of tumor progression
	essential for normal wound healing, where it acts, at least in part, through a TGFBeta-dependent mechanism
	critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory
	required both for fibroblast chemotaxis towards platelet-derived growth factor (PDGF) and growth factor-induced dorsal ruffling
	SEMA7A on keratinocytes and ITGB1 on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, such as psoriasis or wound

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

text	promoting a cell migratory phenotype in association with PRKCA

PATHWAY

metabolism

signaling

ITGB1-WNT7A-DCN pathway promotes proliferation and differentiation of neuroepithelial cells, and identify DCN as a novel neurogenic factor in the central nervous system

a component	dimerizing with ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV (see symbols)
	complexing with PRKCA

INTERACTION

DNA

RNA

small molecule

protein	targeting ERM proteins, MSN, RDX, EZR in association with PRKCA
	YWHAB
	associate with insulin-like growth factor type 1 receptor (IGF-IR) and regulate IGF-stimulated prostate cancer cell proliferation
	interacting with RET (can activate ITGB1, and that RET-induced cell adhesion and migration require ITGB1)
	ITGB1 is a transcriptional target of HOXD1 in endothelial cells
	SERPINB5 physically associates with both PLAUR and ITGB1, thus producing a complex that regulates both cell motility and adhesion
	TLN1 binds to ITGB1 cytoplasmic tails and regulates integrin activation
	PML regulates endothelial cell migration, in part, by modulating expression of downstream genes, such as ITGB1
	NELL1 binds to extracellular ITGB1 and induces cell focal adhesion
	SOX10 and ITGB1 interaction in enteric neural crest cell migration
	ARAP2 and ACAP1 had opposing effects on apparent ITGB1 internalization
	RAB23 promotes squamous cell carcinoma cells migration and invasion by regulating ITGB1/TIAM1/RAC1 pathway
	MARVELD1 regulated neuronal migration by mediating the formation of glial fibres and ITGB1/PTK2 signalling pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   dysregulation of protein expression coexpressed in human prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS