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FLASH GENE

Symbol

B3GALT5

contributors: - updated : 17-11-2003

HGNC name	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
HGNC id	920

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein

basic FUNCTION	mucin glycosylation with a preference for the core 3-O-glycosylation
	catalyzing by N-acetylglucosamine-beta-1,3-galactosyltransferase (beta-3-GalT), which transfers a galactose to an N-acetylglucosamine with a beta-1,3-linkage, resulting in the synthesis of a type 1 Lewis chain.

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	most probable candidate responsible for the synthesis of the type I Lewis antigen in gastrointestinal and pancreatic epithelia and tumor cells derived thereform. Key enzyme that determines the amount of type I Lewis antigen
	including the sialyl Lewis a antigen

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

TCF1

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS