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FLASH GENE

Symbol

B3GALT5

contributors: - updated : 17-11-2003

HGNC name	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
HGNC id	920

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
motif	Viral sequence   long terminal repeat
text structure	one coding exon
	LTR in the promoter activated by HNF1A in the colon and mammary gland

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	five transcripts differing for the 5'utr and encoding an identical protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - initiation site 2760 36 310 - Ishikishi including exons 1, 3, 4 variant 2 - initiation site 2630 36 310 - Ishikishi including exons 1', 3, 4 variant 3 - initiation site - 36 310 trace amounts Ishikishi exons 1, 2, 3, 4 variant 4 - initiation site 2710 36 - trace amounts Ishikishi exons 1, 2, 4 variant 5 - - - - - - Ishikishi exons 1, 3, 4 intron IV3

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         stomach         Endocrine pancreas         Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage
cell lines	adenocarcinoma cell lines (Colo205)
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein

basic FUNCTION	mucin glycosylation with a preference for the core 3-O-glycosylation
	catalyzing by N-acetylglucosamine-beta-1,3-galactosyltransferase (beta-3-GalT), which transfers a galactose to an N-acetylglucosamine with a beta-1,3-linkage, resulting in the synthesis of a type 1 Lewis chain.

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	most probable candidate responsible for the synthesis of the type I Lewis antigen in gastrointestinal and pancreatic epithelia and tumor cells derived thereform. Key enzyme that determines the amount of type I Lewis antigen
	including the sialyl Lewis a antigen

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

TCF1

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS