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FLASH GENE
Symbol TNFSF13 contributors: mct - updated : 19-01-2017
HGNC name tumor necrosis factor (ligand) superfamily, member 13
HGNC id 11928
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • 28AA cytoplasmic domain
  • hydrophobic TM region
  • extracellular domain of 201 amino acids with no signal peptide
    • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Tnfsf13
    Homologene
    FAMILY
  • tumor necrosis factor (ligand) superfamily (TNFSF)
    • CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text type 2 membrane protein
    basic FUNCTION
  • putative regulator of tumor cell growth
  • a proliferation-inducing ligand
  • involved in the regulation of death-ligand-induced apoptotic signaling in malignat glioma cells
  • TNFSF13, TNFSF13B are known to be involved in the occurrence of autoimmune diseases
  • regulator of B-cell-mediated immune responses through the modulation of B-cell survival and activation
  • macrophages express a membrane-bound form of TNFSF13 which, upon stimulation, modulates the activities of macrophages through stimulation or inhibition of processes associated with inflammation
  • TNFSF13, TNFSF13B are members of the TNF superfamily that regulate B-cell survival and autoreactivity
  • TNFSF13, TNFSF13B induced rapid phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) and AKT1 kinases and promoted an increase in human adipose-derived stem cells (hASC) proliferation, without affecting the immunosuppressive capacity of these cells
  • TNFSF13, TNFSF13B play a crucial role in B cell development, survival, and antibody production
  • is a negative regulator of collagen-induced arthritis (CIA) by regulating autoantibody production
  • promotes axon elongation by a mechanism that depends both on ERK signaling and PI3-kinase/AKT1/GSK3B signaling
  • TNFSF13 and FDX1 have potential roles in IgA nephropathy (IgAN)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterotrimer with ANP32B
  • TNFSF13, TNFSF13B assemble as homotrimers that bind and activate several receptors that they partially share
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNFSF13 binding to TNFRSF17 decreases cell proliferation by inducing G(2)/M cell cycle arrest
  • NFKB1 mediates TNFSF13-induced HOXC4 transcription
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in autoimmune disease
    constitutional     --over  
    in monocytes and T cells significantly higher in multiple sclerosis
    constitutional     --over  
    with TNF, TNFSF13B, TNFSF13 in Behcet disease
    constitutional     --over  
    in inflammatory skin lesions of psoriasis
    tumoral     --over  
    in skin squamous cell carcinomas
    tumoral     --over  
    correlates with poor prognosis in clear cell renal cell carcinoma
    tumoral     --over  
    in breast carcinoma tissue lesions
    constitutional     --over  
    in systemic lupus erythematosus (SLE)
    tumoral     --over  
    IRF8 and TNFSF13 expression was significantly higher in lymphomas with IGH rearrangements targeting these loci
    Susceptibility to atrial fibrillation
    Variant & Polymorphism SNP
  • rs11552708 [G/A (G67R)]of TNFSF13 associated with atrial fibrillation
    • Candidate gene
    Marker
  • may be an important marker of disease activity in patients with SLE
  • TNFSF13, TNFSF13B might be useful markers for predicting disease activity in IgG4-related disease
    • Therapy target
    ANIMAL & CELL MODELS