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Symbol TNFSF13 contributors: mct - updated : 19-01-2017
HGNC name tumor necrosis factor (ligand) superfamily, member 13
HGNC id 11928
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in autoimmune disease
constitutional     --over  
in monocytes and T cells significantly higher in multiple sclerosis
constitutional     --over  
with TNF, TNFSF13B, TNFSF13 in Behcet disease
constitutional     --over  
in inflammatory skin lesions of psoriasis
tumoral     --over  
in skin squamous cell carcinomas
tumoral     --over  
correlates with poor prognosis in clear cell renal cell carcinoma
tumoral     --over  
in breast carcinoma tissue lesions
constitutional     --over  
in systemic lupus erythematosus (SLE)
tumoral     --over  
IRF8 and TNFSF13 expression was significantly higher in lymphomas with IGH rearrangements targeting these loci
Susceptibility to atrial fibrillation
Variant & Polymorphism SNP
  • rs11552708 [G/A (G67R)]of TNFSF13 associated with atrial fibrillation
  • Candidate gene
  • may be an important marker of disease activity in patients with SLE
  • TNFSF13, TNFSF13B might be useful markers for predicting disease activity in IgG4-related disease
  • Therapy target