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FLASH GENE
Symbol MAP6 contributors: mct - updated : 28-01-2015
HGNC name microtubule-associated protein 6
HGNC id 6868
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five tandem repeats of 46 amino acids
  • a putative SH3-binding motif near its N terminus
  • calmodulin binding motif
    • HOMOLOGY
    Homologene
    FAMILY
  • STOP family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • the distribution is uniform between the cytoplasm and neurites of neurons
  • colocalizes with neurofilament-rich inclusions in spinal chrod and brain neurons of patients with amyotrophic lateral sclerosis (Letournel 2003)
    • basic FUNCTION
  • acting on the stability and dynamics of microtubules
  • playing an important role for synaptic plasticity
  • microtubule-associated protein stabilizing microtubules in a calmodulin (CaM)-dependent manner
  • is significantly enriched for known tumor suppressors and likely contains many novel tumor suppressors
  • MAP6, MAP6D1 having multimerization activity, which may be relevant to neuronal differentiation and synaptic functions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to microtubules and calmodulin for calmodulin regulation of microtubule dynamics or stability, specifically during mitosis where CaM and MAP6 colocalize
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Map6 deletion in mice severely alters integrated brain functions and is associated with synaptic defects, suggesting that MAP6s may also have alternative cellular roles