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FLASH GENE

Symbol

MAP6

contributors: mct - updated : 28-01-2015

HGNC name	microtubule-associated protein 6
HGNC id	6868

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033063 4 - 2666 NP_149052 - 813 - Letournel (2003) isoform 1 or N-Stop (neuronal-Stop) NM_207577 3 - 4338 NP_997460 - 439 . up-regulated in the prefrontal cortex of patients with schizophrenia (Shimizu 2006) Letournel (2003) isoform 2 or E-Stop (Early-Stop)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive female system uterus         male system prostate         male system testis       Respiratory lung         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	five tandem repeats of 46 amino acids
	a putative SH3-binding motif near its N terminus
	calmodulin binding motif

HOMOLOGY

Homologene

FAMILY

STOP family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	the distribution is uniform between the cytoplasm and neurites of neurons
	colocalizes with neurofilament-rich inclusions in spinal chrod and brain neurons of patients with amyotrophic lateral sclerosis (Letournel 2003)

basic FUNCTION	acting on the stability and dynamics of microtubules
	playing an important role for synaptic plasticity
	microtubule-associated protein stabilizing microtubules in a calmodulin (CaM)-dependent manner
	is significantly enriched for known tumor suppressors and likely contains many novel tumor suppressors
	MAP6, MAP6D1 having multimerization activity, which may be relevant to neuronal differentiation and synaptic functions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

bound to microtubules and calmodulin for calmodulin regulation of microtubule dynamics or stability, specifically during mitosis where CaM and MAP6 colocalize

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Map6 deletion in mice severely alters integrated brain functions and is associated with synaptic defects, suggesting that MAP6s may also have alternative cellular roles