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FLASH GENE

Symbol

ST14

contributors: npt/mct/pgu - updated : 28-08-2015

HGNC name	suppression of tumorigenicity 14 (colon carcinoma)
HGNC id	11344

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ARIH

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in colorectal, breast and ovarian carcinomas tumoral     --over   in ovarian tumors and in cevical carcinoma

Susceptibility

to breast cancer

Variant & Polymorphism other	ST14 variant rs704624 and protein expression of matriptase have prognostic significance in breast cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota