Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ZBTB16

contributors: mct/pgu - updated : 13-12-2023

HGNC name	zinc finger and BTB domain containing 16
HGNC id	12930

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

APLZF

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with RARA, in acute promyelocytic leukaemia and a translocation t(11;17)(q23;21)

Susceptibility

to autism spectrum disorder

Variant & Polymorphism

Candidate gene	represents a promising pleiotropic candidate node for metabolic syndrome
Marker	can be useful as a late marker of osteoblastic differentiation.
	could be a promising tumor biomarker for Gallbladder cancer (GBC)
Therapy target
	System Type Disorder Pubmed osteoarticular bone ostéoporosis Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis cancer digestive liver potential therapeutic target in Gall bladder cancer

ANIMAL & CELL MODELS

	Plzf-deficient mice (luxoid, Zbtb16Lu) had severe patterning defects of the limbs and the axial skeleton
	heterozygous mutant (luxoid.Zbtb16(LU)/J) mice deficient in Zbtb16 have hearing and responses to acoustic trauma similar to their wild type littermates but are unable to generate conditioning-induced protection from acoustic trauma