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FLASH GENE
Symbol ZBTB16 contributors: mct/pgu - updated : 27-03-2013
HGNC name zinc finger and BTB domain containing 16
HGNC id 12930
ASSOCIATED DISORDERS
corresponding disease(s) APLZF
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with RARA, in acute promyelocytic leukaemia and a translocation t(11;17)(q23;21)
Susceptibility to autism spectrum disorder
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Plzf-deficient mice (luxoid, Zbtb16Lu) had severe patterning defects of the limbs and the axial skeleton
  • heterozygous mutant (luxoid.Zbtb16(LU)/J) mice deficient in Zbtb16 have hearing and responses to acoustic trauma similar to their wild type littermates but are unable to generate conditioning-induced protection from acoustic trauma