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FLASH GENE
Symbol ZBTB16 contributors: mct/pgu - updated : 13-12-2023
HGNC name zinc finger and BTB domain containing 16
HGNC id 12930
ASSOCIATED DISORDERS
corresponding disease(s) APLZF
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with RARA, in acute promyelocytic leukaemia and a translocation t(11;17)(q23;21)
Susceptibility to autism spectrum disorder
Variant & Polymorphism
Candidate gene
  • represents a promising pleiotropic candidate node for metabolic syndrome
  • Marker
  • can be useful as a late marker of osteoblastic differentiation.
  • could be a promising tumor biomarker for Gallbladder cancer (GBC)
  • Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneostéoporosis
    Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
    cancerdigestiveliver
    potential therapeutic target in Gall bladder cancer
    ANIMAL & CELL MODELS
  • Plzf-deficient mice (luxoid, Zbtb16Lu) had severe patterning defects of the limbs and the axial skeleton
  • heterozygous mutant (luxoid.Zbtb16(LU)/J) mice deficient in Zbtb16 have hearing and responses to acoustic trauma similar to their wild type littermates but are unable to generate conditioning-induced protection from acoustic trauma