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FLASH GENE
Symbol IGFBP7 contributors: mct - updated : 17-01-2018
HGNC name insulin-like growth factor binding protein 7
HGNC id 5476
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence, highly conserved
  • cysteine-rich N terminus of IGFBP motif
  • kazal-type serine protease inhibitor domain
    • HOMOLOGY
    interspecies homolog to murine Igfbp7
    Homologene
    FAMILY insulin-like growth factor binding protein family
    CATEGORY protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • insuline-like growth factor binding protein 7 (related protein 1)
  • prostacyclin stimulating factor tumor derived adhesion factor
  • inducing senescence and apoptosis through autocrine/paracrine pathways
  • stimulating BNIP3L transcription, at least in part, by increasing intracellular levels of SMARCB1, leading to formation of a SMARCB1-containing SWI/SNF chromatin-remodeling complex, recruited to the BNIP3L promoter and facilitates BNIP3L transcriptional activation
  • factor required for an activated BRAF oncogene to induce senescence or apoptosis in primary human cells (Wajapeyee 2009)
  • functions mostly independent of the IGF signaling pathway and acts as a tumor suppressor in multiple cancers (Huang 2010)
  • can modulate the stimulatory effect of VEGF on angiogenesis by interfering with VEGF expression as well as VEGF signaling and not by inducing apoptosis (Tamura 2009)
  • dispensable for BRAF(V600E)-induced senescence in human melanocytes (Scurr 2010)
  • involved in several cellular processes, including proliferation, senescence and apoptosis (Vizioli 2010)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • part of a pathway in which IGFBP7 increases expression of SMARCB1, which in turn leads to increased expression of BNIP3L culminating in apoptosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in renal clear cell carcinoma with poor prognosis
    tumoral     --over  
    in prostatic cancer
    tumoral     --low  
    is a critical step in melanoma genesis
    tumoral     --low  
  • loss of expression has a functional role in thyroid carcinogenesis (Vizioli 2010)
    • Susceptibility to autism spectrum disorder
    Variant & Polymorphism other
  • functional variant -418G>C in the IGFBP7 promoter is associated with reduced risk of squamous cell carcinoma of head and neck, likely by enhancing the IGFBP7 promoter and DNA-protein binding activities (Huang 2010)
    • Candidate gene
    Marker
  • MYH7, IGFBP7, ANXA2, and DES are all excellent candidate plasma biomarkers of heart failure
    • Therapy target
  • anticancer agent for treatment of metastatic melanoma and other cancers (Wajapeyee 2009)
    • ANIMAL & CELL MODELS